The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …

Neurodegenerative diseases are debilitating disorders that feature progressive and
selective loss of function or structure of anatomically or physiologically associated neuronal …

Parkinson's disease (PD) is a deliberately progressive neurological disorder, arises due to
degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The …

Mitochondria are important integrators of cellular function and therefore affect the
homeostatic balance of the cell. Besides their important role in producing adenosine …

The central nervous system is particularly sensitive to oxidative stress due to many reasons,
including its high oxygen consumption even under basal conditions, high production of …

A chronic inflammatory disease is a condition characterized by persistent inflammation. A
number of human pathologies fall into this category, and a great deal of research has been …

Curcumin, a natural polyphenolic compound extracted from rhizomes of Curcuma longa
(turmeric), a plant in the ginger family (Zingiberaceae) has been used worldwide and …

Parkinson's disease (PD), the second most common neurodegenerative disorder, is
characterized by marked impairments in motor function caused by the progressive loss of …

Cellular models are instrumental in dissecting a complex pathological process into simpler
molecular events. Parkinson's disease is multifactorial and clinically heterogeneous; the …