Transcription factors (TFs) regulate gene expression by binding to DNA sequences and
modulating transcriptional activity through their effector domains. Despite the central role of …

A long-standing question in evolutionary and developmental biology concerns the relative
contribution of cis-regulatory and protein changes to developmental evolution. Central to this …

In this study, we present integrated quantitative proteome, transcriptome, and methylome
analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) …

Background Quantitative reverse transcription–polymerase chain reaction (qRT-PCR) has
been demonstrated to be particularly suitable for the analysis of weakly expressed genes …

Background Transcription regulatory networks are composed of interactions between
transcription factors and their target genes. Whereas unicellular networks have been studied …

Sequence-specific transcription factors (TFs) are important to genetic regulation in all
organisms because they recognize and directly bind to regulatory regions on DNA. Here, we …

Intrinsically disordered regions (IDRs) make up ca. 30% of the proteome of most eukaryotes,
and are involved in a diverse set of functions. Conventional sequence alignment tools …

The form that an animal takes during development is directed by gene regulatory networks
(GRNs). Developmental GRNs interpret maternally deposited molecules and externally …

More than 5% of all genes in the Arabidopsis thaliana genome have been assumed to code
for transcription factors. However, it has been difficult to accurately identify them. To …

It has been shown that alternative splicing is especially prevalent in brain and testis when
compared to other tissues. To test whether there is a specific propensity of these tissues to …