[HTML][HTML] Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses
C Yujuan, LIN Junhong, Z Yao… - Journal of Zhejiang …, 2021 - ncbi.nlm.nih.gov
Abstract Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the
transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and …
transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and …
ERK1/2 in immune signalling
Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the
mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a …
mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a …
[HTML][HTML] Recent advances in the development of toll-like receptor agonist-based vaccine adjuvants for infectious diseases
JX Yang, JC Tseng, GY Yu, Y Luo, CYF Huang… - Pharmaceutics, 2022 - mdpi.com
Vaccines are powerful tools for controlling microbial infections and preventing epidemic
diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and …
diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and …
Genomics of Alzheimer's disease implicates the innate and adaptive immune systems
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …
Signalling, sorting and scaffolding adaptors for Toll-like receptors
Toll-like receptors (TLRs) are danger-sensing receptors that typically propagate self-limiting
inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or …
inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or …
[HTML][HTML] SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages
Immune cells are armed with Toll-like receptors (TLRs) for sensing and responding to
pathogens and other danger cues. The role of extracellular-signal-regulated kinases 1/2 …
pathogens and other danger cues. The role of extracellular-signal-regulated kinases 1/2 …
Apolipoprotein C3 (ApoC3) facilitates NLRP3 mediated pyroptosis of macrophages through mitochondrial damage by accelerating of the interaction between SCIMP …
Z Pu, W Wang, H Xie, W Wang - International Immunopharmacology, 2024 - Elsevier
Respiratory failure caused by severe acute lung injury (ALI) is the main cause of mortality in
patients with COVID-19. This study aimed to investigate the effects and underlying biological …
patients with COVID-19. This study aimed to investigate the effects and underlying biological …
[HTML][HTML] The transmembrane adapter SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs
Innate immune signaling by Toll-like receptors (TLRs) involves receptor phosphorylation,
which helps to shape and drive key inflammatory outputs, yet our understanding of the …
which helps to shape and drive key inflammatory outputs, yet our understanding of the …
TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages
TLRs engage numerous adaptor proteins and signaling molecules, enabling a complex
series of post‐translational modifications (PTMs) to mount inflammatory responses. TLRs …
series of post‐translational modifications (PTMs) to mount inflammatory responses. TLRs …
Macropinocytic cups function as signal platforms for the mTORC2-AKT pathway to modulate LPS-induced cytokine expression in macrophages
L Wang, X Sun, J Chen, Y Li, Y He, J Wei… - Journal of Leukocyte …, 2024 - academic.oup.com
Macropinocytosis is a large-scale endocytosis process primarily observed in phagocytes as
part of their cellular function to ingest antigens. Once phagocytes encounter gram-negative …
part of their cellular function to ingest antigens. Once phagocytes encounter gram-negative …