Diagnosis of neonatal sepsis: the past, present and future

IH Celik, M Hanna, FE Canpolat, M Pammi - Pediatric research, 2022 - nature.com
Sepsis remains a significant cause of neonatal mortality and morbidity, especially in low-and
middle-income countries. Neonatal sepsis presents with nonspecific signs and symptoms …

[HTML][HTML] Relevance of biomarkers currently in use or research for practical diagnosis approach of neonatal early-onset sepsis

MA Hincu, GI Zonda, GD Stanciu, D Nemescu… - Children, 2020 - mdpi.com
Neonatal early-onset sepsis (EOS) is defined as an invasive infection that occurs in the first
72 h of life. The incidence of EOS varies from 0.5–2% live births in developed countries, up …

[HTML][HTML] Biomarkers of neonatal sepsis: where we are and where we are going

G Boscarino, R Migliorino, G Carbone, G Davino… - Antibiotics, 2023 - mdpi.com
Neonatal sepsis is a bacterial bloodstream infection leading to severe clinical manifestations
frequently associated with death or irreversible long-term deficits. Antibiotics are the drug of …

[HTML][HTML] Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression

A Garduno, R Cusack, M Leone, S Einav… - Microorganisms, 2023 - mdpi.com
It is evident that the admission of some patients with sepsis and septic shock to hospitals is
occurring late in their illness, which has contributed to the increase in poor outcomes and …

The inflammation network in the pathogenesis of erectile dysfunction: attractive potential therapeutic targets

E Kaya-Sezginer, S Gur - Current Pharmaceutical Design, 2020 - ingentaconnect.com
Background: Erectile dysfunction (ED) is an evolving health problem in the aging male
population. Chronic low-grade inflammation is a critical component of ED pathogenesis and …

[HTML][HTML] The endothelial glycocalyx and neonatal sepsis

A Fatmi, W Saadi, J Beltrán-García… - International Journal of …, 2022 - mdpi.com
Sepsis carries a substantial risk of morbidity and mortality in newborns, especially preterm-
born neonates. Endothelial glycocalyx (eGC) is a carbohydrate-rich layer lining the vascular …

[HTML][HTML] Analysis of inflammatory mediator profiles in sepsis patients reveals that extracellular histones are strongly elevated in nonsurvivors

T Eichhorn, I Linsberger, L Lauková… - Mediators of …, 2021 - hindawi.com
The timely recognition of sepsis and the prediction of its clinical course are challenging due
to the complex molecular mechanisms leading to organ failure and to the heterogeneity of …

Diagnostic value of maternal, cord blood and neonatal biomarkers for early onset sepsis: a systematic review and meta-analysis

LM van Leeuwen, E Fourie, G van den Brink… - Clinical Microbiology …, 2024 - Elsevier
Background An accurate diagnosis of early onset sepsis (EOS) is challenging due to subtle
symptoms and the lack of a good diagnostic tool, resulting in considerable antibiotic …

[HTML][HTML] Acute clinical syndromes and suspicion of SARS-CoV-2 infection: the experience of a single Romanian center in the early pandemic period

RE Haliga, V Sorodoc, C Lionte, OR Petris, C Bologa… - Medicina, 2021 - mdpi.com
Background and Objectives: During the coronavirus disease 2019 (COVID-19) pandemic,
patients with chronic diseases suffering exacerbations have required acute medical care …

[HTML][HTML] Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A …

MA Hincu, GI Zonda, P Vicoveanu, V Harabor… - Children, 2024 - mdpi.com
(1) Background: Neonatal early-onset sepsis (EOS) is associated with important mortality
and morbidity. The aims of this study were to evaluate the association between serum and …