Tuberous sclerosis (also known as tuberous sclerosis complex [TSC]) is a multisystem
genetic disorder that affects almost every organ in the body. Mutations in the TSC1 or TSC2 …

The cerebellum contains the largest number of neurons and synapses of any structure in the
central nervous system. The concept that the cerebellum is solely involved in fine motor …

There is an increasing recognition of clinical overlap in patients presenting with epilepsy
and autism spectrum disorder (ASD), and a great deal of new information regarding the …

Epilepsy surgery is highly successful in achieving seizure freedom in carefully selected
children with drug‐resistant focal epilepsy. Advances in technology have aided presurgical …

Objective: The purpose of this study was to assess the prevalence of and to identify
epidemiologic, genetic, electrophysiologic, and neuroanatomic risk factors for autism …

Infantile spasms constitute an age-dependent epilepsy, highly associated with cognitive
impairment, autism, and movement disorders. Previous classification systems focused on a …

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the
development of widespread hamartomatous lesions in various organs, including brain, skin …

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by
mutations in Tsc1 or Tsc2 that lead to mammalian target of rapamycin (mTOR) hyperactivity …

Tuberous sclerosis complex (TSC) is a model disorder for understanding brain development
because the genes that cause TSC are known, many downstream molecular pathways have …

Introduction. The mammalian target of rapamycin (mTOR) pathway has emerged as a key
player for proper neural network development, and it is involved in epileptogenesis triggered …