Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Emerging evidence indicates that the accretion of senescent cells is linked to metabolic
disorders. However, the underlying mechanisms and metabolic consequences of cellular …

Paired box 4 (Pax4) is a key transcription factor involved in the embryonic development of
the pancreatic islets of Langerhans. Consisting of a conserved paired box domain and a …

Adipocytes have unique morphological traits in insulin sensitivity control. However, how the
appearance of adipocytes can determine insulin sensitivity has not been understood. Here …

Adipose tissue is the key organ coordinating whole-body energy homeostasis. Although it
has been reported that ring finger protein 20 (RNF20) regulates lipid metabolism in the liver …

Obesity in pregnant mothers often leads to a range of obstetric complications, including
miscarriage, pre‑eclampsia, gestational hypertension and diabetes. C1q/TNF‑related protein …

Our ever-changing modern environment is a significant contributor to the increased
prevalence of many chronic diseases, and particularly, type 2 diabetes mellitus (T2DM) …

The impairment of pancreatic β-cells function is partly caused by lipotoxicity, which
aggravates the development of type 2 diabetes mellitus. Activator Protein 1 member JunD …

Background Alternative and complementary therapies play an imperative role in the clinical
management of Type 2 diabetes mellitus (T2DM), and exploring and utilizing natural …

Mitochondria are fundamental but complex determinants for hematopoietic stem cell (HSC)
maintenance. However, the factors involved in the regulation of mitochondrial metabolism in …