Toll-like receptors (TLRs) in innate immune cells are the prime cellular sensors for microbial
components. TLR activation leads to the production of proinflammatory mediators and thus …

Periodontal disease (PD) and cardiovascular disease (CVD) are highly prevalent in the
modern community. Both pathologies are chronic inflammatory disorders, which are …

The aim of this review was to update the evidence of new approaches to non-surgical
therapy (NSPT) in the treatment of periodontitis. Preclinical and clinical studies addressing …

MicroRNAs (miRNAs) have been demonstrated to play an important role in regulation of the
immuno‐inflammatory response; however, the function of miRNAs in periodontal …

To gain insights into the in vivo function of miRNAs in the context of periodontitis, we
examined the occurrence of miRNAs in healthy and diseased gingival tissues and validated …

Periodontitis, an oral chronic inflammatory disease, is reported to show an association with
atherosclerotic vascular disease. Fusobacterium nucleatum is an oral commensal bacterium …

The aim of this pilot investigation was to determine if microRNA expression differed in the
presence or absence of obesity, comparing gingival biopsies obtained from patients with or …

Innate immune response is the first defense against pathogens via recognition by various
conserved pattern recognition receptors, such as TLRs, to initiate a rapid and strong …

Background: The aim of this study is to characterize and evaluate the host response caused
by three different models of experimental periodontitis in mice. Methods: C57BL/6 wild‐type …

The innate immune system recognizes invading pathogens through germline-encoded
pattern recognition receptors (PRRs), which elicit innate antimicrobial and inflammatory …