Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

In bone biology, epigenetics plays a key role in mesenchymal stem cells'(MSCs)
commitment towards osteoblasts. It involves gene regulatory mechanisms governed by …

Imbalance of bone homeostasis induces bone degenerative diseases such as osteoporosis.
Hedgehog (Hh) signaling plays critical roles in regulating the development of limb and joint …

Despite the identification of several genetic factors linked to increased susceptibility to
inflammatory bowel disease (IBD), underlying molecular mechanisms remain to be …

Osteoporosis is a systemic degenerative bone disease characterized by low bone mass and
damage to bone microarchitecture, which increases bone fragility and susceptibility to …

Bone remodeling is a complex physiological process that spans across multiple spatial and
temporal scales and is regulated by both mechanical and hormonal cues. An imbalance …

Epigenetic regulation plays an essential role in driving precise transcriptional programs
during development and homeostasis. Among epigenetic mechanisms, histone mono …

Bone metabolism plays a crucial role in maintaining normal bone tissue homeostasis and
function. Imbalances between bone formation and resorption can lead to osteoporosis …

The HER2-positive breast cancer subtype (HER2+-BC) displays a particularly aggressive
behavior. Anti-HER2 therapies have significantly improved the survival of patients with …

Monoubiquitination plays a critical role as one of the largest histone post-translational
modifications (PTMs). Recent study has revealed that histone H2B monoubiquitination …