Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Over 30 million people suffer from the consequences of ischemic stroke. The precise
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …

Ischaemic stroke is becoming the most common cerebral disease in aging populations, but
the underlying molecular mechanism of the disease has not yet been fully elucidated …

Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …

Stroke is a common and serious nervous system disease caused by the rupture or blockage
of the cardiovascular system. It causes millions of deaths and disabilities every year, which …

Increasingly, perturbations in cellular iron and ferritin are emerging as an important element
in the pathogenesis of disease. These changes in ferritin are important not only in the classic …

Ferroptosis is a unique regulated cell death defined by the intracellular iron overload and
distinct biological features compared with other well-known programmed cell death …

Neurons need iron, which is reflected in their expression of the transferrin receptor. The
concurrent expression of the ferrous iron transporter, divalent metal transporter I (DMT1), in …

Overproduction of reactive oxygen species under pathophysiological conditions, including
dyslipidemia, hypertension, diabetes, and smoking, is integral in the development of …

Oxidative stress plays an important role in neuronal injuries caused by cerebral ischemia. It
is well established that free iron increases significantly during ischemia and is responsible …