[HTML][HTML] Moderate aerobic training inhibits middle-aged induced cardiac calcineurin-NFAT signaling by improving TGF-ß, NPR-A, SERCA2, and TRPC6 in Wistar rats

B Baghaiee, R Bayatmakoo, P Karimi… - Cell Journal …, 2021 - ncbi.nlm.nih.gov
Objective The purpose of this study was to investigate the effect of moderate-intensity
training on the calcineurin/nuclear factor of activated t-cells (NFAT) pathway and factors …

[HTML][HTML] Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway

C Li, S Jiang, H Wang, Y Wang, Y Han… - Biomedicine & …, 2022 - Elsevier
Berberine (BBR), an isoquinoline alkaloid, exerts protective effects on various cardiac
injuries, and also extends the lifespan of individuals. However, the cardioprotective effect of …

Skeletal Muscle Injury in Chronic Kidney Disease—From Histologic Changes to Molecular Mechanisms and to Novel Therapies

K Heitman, MS Alexander, C Faul - International Journal of Molecular …, 2024 - mdpi.com
Chronic kidney disease (CKD) is associated with significant reductions in lean body mass
and in the mass of various tissues, including skeletal muscle, which causes fatigue and …

Involvement of sirtuins and klotho in cardioprotective effects of exercise training against waterpipe tobacco smoking-induced heart dysfunction

SS Alavi, S Joukar, F Rostamzadeh… - Frontiers in …, 2021 - frontiersin.org
Despite its negative effect on the cardiovascular system, waterpipe smoking (WPS) is
currently popular worldwide, especially among youth. This study investigated the effects of …

[HTML][HTML] The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats

LE Engel, FLA de Souza, IC Giometti, K Okoshi… - Life Sciences, 2022 - Elsevier
Aim To evaluate the influence of high-intensity interval training (HIIT) on cardiac structural
and functional characteristics and myocardial mitogen-activated protein kinase (MAPK) …

Novel prevention insights into depletion of oxidative stress status through regular exercise and grape seed effective substance in heart ischemia rat model

S Zarei, F Taghian, G Sharifi… - Food Science & Nutrition, 2022 - Wiley Online Library
Myocardial ischemia (MI) is recognized as the most frequent cardiovascular disease which
is the dominant cause of global morbidity and mortality. Artificial intelligence tools and …

[HTML][HTML] The protective effect of Apelin-13 against cardiac hypertrophy through activating the PI3K-AKT-mTOR signaling pathway

Y Peng, R Jingming, C Shaowen, H Feng… - Iranian Journal of …, 2023 - ncbi.nlm.nih.gov
Objective (s): To determine the protective effect of Apelin-13 on cardiac hypertrophy through
activating the PI3K-AKT-mTOR signaling pathway. Materials and Methods: The …

Cardiotoxicity and cardioprotection by artesunate in larval zebrafish

C Zheng, L Shan, P Tong, T Efferth - Dose-Response, 2020 - journals.sagepub.com
Although artesunate (ART) is generally accepted as a safe and well-tolerated first-line
treatment of severe malaria, cases of severe side effects and toxicity of this compound are …

Exercise training attenuates cardiac vulnerability and promotes cardiac resistance to isoproterenol-induced injury following hookah smoke inhalation in male rats: role …

SS Alavi, S Joukar, F Rostamzadeh… - Cardiovascular …, 2022 - Springer
Hookah smoking is on the rise around the world. Present study investigated the heart
resistance to harmful stress following long-term waterpipe tobacco smoking (WTS) and …

Impact of a single bout of resistance exercise on serum Klotho in healthy young men

T Morishima, E Ochi - Physiological Reports, 2021 - Wiley Online Library
Background It has been shown that Klotho protects vascular endothelial function. Given that
a single bout of resistance‐exercise‐induced hypertensive stimulus causes endothelial …