Histones and their post-translational modifications have key roles in chromatin remodeling
and gene transcription. Besides intranuclear functions, histones act as damage-associated …

Neutrophil NETosis is an important element of host defense as it catapults chromatin out of
the cell to trap bacteria, which then are killed, eg, by the chromatin's histone component …

Obesity-linked insulin resistance greatly increases the risk for type 2 diabetes, hypertension,
dyslipidemia, and non-alcoholic fatty liver disease, together known as the metabolic or …

In inflammation, extensive cell death may occur, which results in the release of chromatin
components into the extracellular environment. Individually, the purified chromatin …

Liquid biopsies have emerged as a minimally invasive cancer detection and monitoring
method, which could identify cancer-related alterations in nucleosome or histone levels and …

The calcium-permeable ion channel TRPM2 is highly expressed in a number of cancers. In
neuroblastoma, full-length TRPM2 (TRPM2-L) protected cells from moderate oxidative stress …

Cigarette smoke (CS)-mediated oxidative stress induces several signaling cascades,
including kinases, which results in chromatin modifications (histone acetylation …

Cardiac TRPM2 channels were activated by intracellular adenosine diphosphate-ribose and
blocked by flufenamic acid. In adult cardiac myocytes the ratio of G Ca to G Na of TRPM2 …

Chronic obstructive pulmonary disease (COPD) is a leading cause of death due to tis high
morbidity and mortality. microRNAs have emerged as new biomarkers for the prognosis and …

Post-translational modifications (PTMs) can occur soon after translation or at any stage in
the lifecycle of a given protein, and they may help regulate protein folding, stability, cellular …