DNA methylation profiling: an emerging paradigm for cancer diagnosis
A Papanicolau-Sengos, K Aldape - Annual Review of Pathology …, 2022 - annualreviews.org
Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …
Current recommendations and recent progress in endometrial cancer
RA Brooks, GF Fleming, RR Lastra… - CA: a cancer journal …, 2019 - Wiley Online Library
Endometrial cancer is the most common gynecologic cancer in the United States, and its
incidence is rising. Although there have been significant recent advances in our …
incidence is rising. Although there have been significant recent advances in our …
[PDF][PDF] Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
A Oaknin, TJ Bosse, CL Creutzberg, G Giornelli… - Annals of oncology, 2022 - Elsevier
Highlights•This ESMO Clinical Practice Guideline provides key recommendations for
managing endometrial cancer.•The guideline covers clinical and pathological diagnosis …
managing endometrial cancer.•The guideline covers clinical and pathological diagnosis …
[HTML][HTML] Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer
KA Hoadley, C Yau, T Hinoue, DM Wolf, AJ Lazar… - Cell, 2018 - cell.com
We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …
Clinical actionability of molecular targets in endometrial cancer
ME Urick, DW Bell - Nature Reviews Cancer, 2019 - nature.com
Abstract Endometrial cancer accounts for~ 76,000 deaths among women each year
worldwide. Disease mortality and the increasing number of new diagnoses make …
worldwide. Disease mortality and the increasing number of new diagnoses make …
A comprehensive pan-cancer molecular study of gynecologic and breast cancers
We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of
four gynecological types plus breast. Our aims were to identify shared and unique molecular …
four gynecological types plus breast. Our aims were to identify shared and unique molecular …
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex
SA Welsh, A Gardini - Nature Reviews Molecular Cell Biology, 2023 - nature.com
In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …
Clinical significance of FBXW7 loss of function in human cancers
J Fan, M Bellon, M Ju, L Zhao, M Wei, L Fu, C Nicot - Molecular cancer, 2022 - Springer
Abstract FBXW7 (F-Box and WD Repeat Domain Containing 7)(also referred to as FBW7 or
hCDC4) is a component of the Skp1-Cdc53/Cullin-F-box-protein complex (SCF/β-TrCP). As …
hCDC4) is a component of the Skp1-Cdc53/Cullin-F-box-protein complex (SCF/β-TrCP). As …
SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions
We report a new class of artifacts in DNA methylation measurements from Illumina
HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed …
HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed …
New pathological and clinical insights in endometrial cancer in view of the updated ESGO/ESTRO/ESP guidelines
Simple Summary Histopathological classification of endometrial carcinoma has evidenced
two main groups with different biological behavior: low-grade (G1–G2) and high-grade (G3) …
two main groups with different biological behavior: low-grade (G1–G2) and high-grade (G3) …