Precisely controlled cell deformations are key to cell migration, division and tissue
morphogenesis, and have been implicated in cell differentiation during development, as well …

Actomyosin-mediated contractility is a highly conserved mechanism for generating
mechanical stress in animal cells and underlies muscle contraction, cell migration, cell …

When animal cells enter mitosis, they round up to become spherical. This shape change is
accompanied by changes in mechanical properties. Multiple studies using different …

The cortex is a thin, crosslinked actin network lying immediately beneath the plasma
membrane of animal cells. Myosin motors exert contractile forces in the meshwork. Because …

Cancer cells are defined by their ability to invade through the basement membrane, a critical
step during metastasis. While increased secretion of proteases, which facilitates degradation …

Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In
animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase …

Cytokinesis mediates the physical separation of dividing cells after chromosome
segregation. In animal cell cytokinesis, a contractile ring, mainly composed of actin and …

Cytokinesis is the process by which mitotic cells physically split in two following
chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then …

Mechanical forces direct a host of cellular and tissue processes. Although much emphasis
has been placed on cell-adhesion complexes as force sensors, the forces must nevertheless …

We describe an active polymer network in which processive molecular motors control
network elasticity. This system consists of actin filaments cross-linked by filamin A (FLNa) …