Monocarboxylate transporters (SLC16): function, regulation, and role in health and disease

MA Felmlee, RS Jones, V Rodriguez-Cruz… - Pharmacological …, 2020 - ASPET
The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate
transporter (MCT) family that play an essential role in the transport of important cell nutrients …

Epigenetic Dysregulation in MYCN-Amplified Neuroblastoma

S Epp, SM Chuah, M Halasz - International Journal of Molecular Sciences, 2023 - mdpi.com
Neuroblastoma (NB), a childhood cancer arising from the neural crest, poses significant
clinical challenges, particularly in cases featuring amplification of the MYCN oncogene …

Genome-wide methylation profiling identifies novel methylated genes in neuroblastoma tumors

M Olsson, S Beck, P Kogner, T Martinsson, H Carén - Epigenetics, 2016 - Taylor & Francis
Neuroblastoma is a very heterogeneous tumor of childhood. The clinical spectra range from
very aggressive metastatic disease to spontaneous regression, even without therapy …

[HTML][HTML] MYCN in neuroblastoma:“old wine into new wineskins”

M Braoudaki, K Hatziagapiou, A Zaravinos, GI Lambrou - Diseases, 2021 - mdpi.com
MYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most
studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its …

Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors

YS Hsueh, HH Chang, YS Shan, HS Sun, JA Fletcher… - Oncogene, 2019 - nature.com
Gastrointestinal stromal tumors (GISTs) are frequently driven by auto-activated, mutant KIT
and have durable response to KIT tyrosine kinase inhibitor. However, acquired resistance is …

Solute carrier family 16 member 5 downregulation and its methylation might serve as a prognostic indicator of prostate cancer

X Meng, H Yuan, W Li, Z Xiong, W Dong, W Xiao… - IUBMB …, 2021 - Wiley Online Library
Prostate cancer (PCa), characterized by high invasion, metastasis, and recurrence, is the
most prevalent malignant tumor in men worldwide. A clear understanding of the underlying …

[PDF][PDF] Genome-wide association study on growth traits in Colombian creole breeds and crossbreeds with Zebu cattle

R Martínez, Y Gómez, JFM Rocha - Genet Mol Res, 2014 - geneticsmr.com
Whole genome selection represents an important tool for improving parameters related to
the production of livestock. In order to build genomic selection indexes within a particular …

Promoter hypomethylation of RAR-related orphan receptor α 1 is correlated with unfavorable clinicopathological features in patients with colorectal cancer

H Kano, T Takayama, Y Midorikawa, H Nagase - BioScience Trends, 2016 - jstage.jst.go.jp
Retinoic acid receptor-related orphan receptor α (RORA) is a tumor-specific differentially
methylated region. RORA mRNA expression is frequently downregulated in colorectal …

Monocarboxylic Acid Transporters

ME Morris, NV Kwatra - Drug Transporters: Molecular …, 2022 - Wiley Online Library
Monocarboxylate transporters (or MCTs) are widely distributed in the body and responsible
for the uptake of short‐chain monocarboxylates, hormones, nutrients, amino acids, as well …

[PDF][PDF] MYCN in Neuroblastoma:“Old Wine into New Wineskins”. Diseases 2021, 9, 78

MYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most
studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its …