Insula function is considered critical for many motivated behaviors, with proposed functions
ranging from attention, behavioral control, emotional regulation, goal-directed and aversion …

Substance use disorders (SUDs) are a growing public health concern with only a limited
number of approved treatments. However, even approved treatments are subject to limited …

Despite decades of research on neurobiological mechanisms of psychostimulant addiction,
the only effective treatment for many addicts is contingency management, a behavioral …

Abstract MCGREGOR, MS, and RT LaLumiere. Still a “hidden island”? The rodent insular
cortex in drug seeking, reward, and risk. NEUROSCI BIOBEHAV REV 21 (1) XXX-XXX …

Compulsion-like alcohol drinking (CLAD), where consumption continues despite negative
consequences, is a major obstacle to treating alcohol use disorder. The locus coeruleus …

Humans with alcohol use disorder typically abstain because of the negative consequences
associated with excessive drinking, and exposure to contexts previously associated with …

Substance use disorder (SUD) is characterized, in part by behavior biased toward drug use
and away from natural sources of reward (eg, social interaction, food, sex). The …

Drugs of abuse, including alcohol, ablate the expression of specific forms of long-term
synaptic depression (LTD) at glutamatergic synapses in dorsal striatum (DS), a brain region …

Empathy, the understanding of the emotional state of others, can be examined across
species using the Perception Action Model, where shared affect promotes an action by …

Transcranial Magnetic Stimulation (TMS) is earning a role in the therapeutic arsenal of
cocaine use disorder (CUD). A widespread and still growing number of studies have …