Museum of spatial transcriptomics

L Moses, L Pachter - Nature methods, 2022 - nature.com
The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …

Aging and urinary control: Alterations in the brain–bladder axis

CC Hardy, R Korstanje - Aging cell, 2023 - Wiley Online Library
Age‐associated alterations in bladder control affect millions of older adults, with a heavy
burden added to families both economically and in quality of life. Therapeutic options are …

[HTML][HTML] Cancer-associated fibroblasts in bladder cancer: origin, biology, and therapeutic opportunities

B Caramelo, S Zagorac, S Corral, M Marqués… - European Urology …, 2023 - Elsevier
Context Bladder cancer (BLCA) is a highly prevalent tumour and a health problem
worldwide, especially among men. Recent work has highlighted the relevance of the tumour …

Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics

IM Al‐Naggar, M Antony, D Baker, L Wang… - Aging …, 2024 - Wiley Online Library
Lower urinary tract dysfunction (LUTD) increases with aging. Ensuing symptoms including
incontinence greatly impact quality of life, isolation, depression, and nursing home …

Defining the molecular fingerprint of bladder and kidney fibroblasts

G Apodaca - American Journal of Physiology-Renal …, 2023 - journals.physiology.org
Fibroblasts are integral to the organization and function of all organs and play critical roles in
pathologies such as fibrosis; however, we have limited understanding of the fibroblasts that …

Loss of resilience contributes to detrusor underactivity in advanced age

R Ramasamy, DS Baker, F Lemtiri-Chlieh… - Biogerontology, 2023 - Springer
Volume hyposensitivity resulting from impaired sympathetic detrusor relaxation during
bladder filling contributes to detrusor underactivity (DU) associated with aging. Detrusor …

The hyperpolarization-activated, cyclic nucleotide-gated channel resides on myocytes in mouse bladders and contributes to adrenergic-induced detrusor relaxation

F Lemtiri-Chlieh, DS Baker… - American Journal …, 2022 - journals.physiology.org
Control of urinary continence is predicated on sensory signaling about bladder volume.
Bladder sensory nerve activity is dependent on tension, implicating autonomic control over …

[HTML][HTML] Deconstructing Organs: Single-Cell Analyses, Decellularized Organs, Organoids, and Organ-on-a-Chip Models: The hyperpolarization-activated, cyclic …

F Lemtiri-Chlieh, DS Baker, IM Al-Naggar… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Control of urinary continence is predicated on sensory signaling about bladder volume.
Bladder sensory nerve activity is dependent on tension, implicating autonomic control over …