Ageing is a complex trait controlled by genes and the environment. The highly conserved
mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan …

Cells survey their environment and need to balance growth and anabolism with stress
programmes and catabolism towards maximum cellular bioenergetics economy and …

Cell size varies during the cell cycle and in response to external stimuli. This requires the
tight coordination, or" scaling," of mRNA and protein quantities with the cell volume in order …

The packaging of the genetic material into chromatin imposes the remodeling of this barrier
to allow efficient transcription. RNA polymerase II activity is coupled with several histone …

The fission yeast Schizosaccharomyces pombe employs two main strategies to adapt to the
environment and survive when starved for nutrients. The strategies employ sporulation via …

Transfer RNAs (tRNAs) mainly function as adapter molecules that decode messenger RNAs
(mRNAs) during protein translation by delivering amino acids to the ribosome. Traditionally …

The relationship between transcription and aging is one that has been studied intensively
and experimentally with diverse attempts. However, the impact of the nuclear mRNA export …

When glucose is available, many organisms repress mitochondrial respiration in favour of
aerobic glycolysis, or fermentation in yeast, that suffices for ATP production. Fission yeast …

In the fission yeast Schizosaccharomyces pombe, the duration of survival in the stationary
phase, termed the chronological lifespan (CLS), is affected by various environmental factors …

Many proteins remain poorly characterized even in well-studied organisms, presenting a
bottleneck for research. We applied phenomics and machine-learning approaches with …