Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Pathological hallmarks of Alzheimer's disease (AD) precede clinical symptoms by years,
indicating a period of cognitive resilience before the onset of dementia. Here, we report that …

Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Impaired
neuronal bioenergetics and neuroinflammation are thought to play key roles in the …

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Abstract Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules
that are ubiquitous across species ranging from viruses to mammals. Important advances …

The cGAS-STING pathway is essential for immune defense against microbial pathogens and
malignant cells; as such, STING is an attractive target for cancer immunotherapy. However …

Immune-checkpoint inhibitors and chimeric antigen receptor (CAR) T cells are
revolutionizing oncology and haematology practice. With these and other immunotherapies …

Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5′
or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA …