[HTML][HTML] The oralome and its dysbiosis: New insights into oral microbiome-host interactions

A Radaic, YL Kapila - Computational and structural biotechnology journal, 2021 - Elsevier
The oralome is the summary of the dynamic interactions orchestrated between the
ecological community of oral microorganisms (comprised of up to approximately 1000 …

Biofilm control by interfering with c-di-GMP metabolism and signaling

X Liu, B Cao, L Yang, JD Gu - Biotechnology Advances, 2022 - Elsevier
Biofilm formation and biofilm-induced biodeterioration of surfaces have deeply affected the
life of our community. Cyclic dimeric guanosine monophosphate (c-di-GMP) is a small …

The association between biofilm formation and antimicrobial resistance with possible ingenious bio-remedial approaches

Y Dutt, R Dhiman, T Singh, A Vibhuti, A Gupta… - Antibiotics, 2022 - mdpi.com
Biofilm has garnered a lot of interest due to concerns in various sectors such as public
health, medicine, and the pharmaceutical industry. Biofilm-producing bacteria show a …

Multiple roles of c-di-GMP signaling in bacterial pathogenesis

M Valentini, A Filloux - Annual review of microbiology, 2019 - annualreviews.org
The intracellular signaling molecule cyclic di-GMP (c-di-GMP) regulates the lifestyle of
bacteria and controls many key functions and mechanisms. In the case of bacterial …

Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation

K Qvortrup, LD Hultqvist, M Nilsson… - Frontiers in …, 2019 - frontiersin.org
Microbial biofilms are the cause of persistent infections associated with various medical
implants and distinct body sites such as the urinary tract, lungs, and wounds. Compared with …

Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

JB Andersen, LD Hultqvist, CU Jansen… - NPJ biofilms and …, 2021 - nature.com
Microbial biofilms are involved in a number of infections that cannot be cured, as microbes in
biofilms resist host immune defenses and antibiotic therapies. With no strict biofilm-antibiotic …

Inhibitors of bacterial swarming behavior

S Rütschlin, T Böttcher - Chemistry–A European Journal, 2020 - Wiley Online Library
Bacteria can migrate in groups of flagella‐driven cells over semisolid surfaces. This
coordinated form of motility is called swarming behavior. Swarming is associated with …

Biofilm matrix disrupts nematode motility and predatory behavior

SY Chan, SY Liu, Z Seng, SL Chua - The ISME journal, 2021 - academic.oup.com
In nature, bacteria form biofilms by producing exopolymeric matrix that encases its entire
community. While it is widely known that biofilm matrix can prevent bacterivore predation …

Controlling biofilm development through cyclic di-GMP signaling

S Park, K Sauer - Pseudomonas aeruginosa: Biology, Pathogenesis and …, 2022 - Springer
The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that
regulates many bacterial behaviors and is of key importance for driving the lifestyle switch …

Bacterial biofilm control by perturbation of bacterial signaling processes

TH Jakobsen, T Tolker-Nielsen, M Givskov - International Journal of …, 2017 - mdpi.com
The development of effective strategies to combat biofilm infections by means of either
mechanical or chemical approaches could dramatically change today's treatment …