Autophagy is a critical regulator of cellular survival, differentiation, development, and
homeostasis, dysregulation of which is associated with diverse diseases including cancer …

Our previous studies showed that silent mating-type information regulation 2 homologue-1
(SIRT1, a deacetylase) upregulation could attenuate sepsis-induced acute kidney injury …

The degradation of macromolecules and organelles by the process of autophagy is critical
for cellular homeostasis and is often compromised during aging and disease. Beclin1 and …

Harnessing the immunomodulatory ability of the microbiota, such as fecal microbiota
transplantation (FMT), has emerged as a promising strategy to improve cancer …

Vesicles are loaded with a variety of cargoes, including membrane proteins, secreted
proteins, signaling molecules, and various enzymes, etc. Not surprisingly, vesicle transport …

Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors that are harmful to
human health. Increasing evidence has underscored the critical role of the competitive …

Macroautophagy/autophagy-related proteins regulate infectious and inflammatory diseases
in autophagy-dependent or-independent manner. However, the role of a newly identified …

Synovial macrophage polarization and inflammation are essential for osteoarthritis (OA)
development, yet the molecular mechanisms and regulation responsible for the …

Lymphoma is a common malignant tumor globally. Tumor-derived extracellular vesicles
(Evs) participate in genetic information exchange between tumor cells. We investigated the …

Background Parkinson's disease (PD) is a well-known neurodegenerative disease that is
usually caused by the progressive loss of dopamine neurons and the formation of Lewy …