Pathological Interplay between Inflammation and Mitochondria Aggravates Glutamate Toxicity
A Vaglio-Garro, AV Kozlov, YD Smirnova… - International Journal of …, 2024 - mdpi.com
Mitochondrial dysfunction and glutamate toxicity are associated with neural disorders,
including brain trauma. A review of the literature suggests that toxic and transmission actions …
including brain trauma. A review of the literature suggests that toxic and transmission actions …
Pentylenetetrazole-induced seizures are increased after kindling, exhibiting vitamin-responsive correlations to the post-seizures behavior, amino acids metabolism …
VA Aleshin, AV Graf, AV Artiukhov… - International Journal of …, 2023 - mdpi.com
Epilepsy is characterized by recurrent seizures due to a perturbed balance between
glutamate and GABA neurotransmission. Our goal is to reveal the molecular mechanisms of …
glutamate and GABA neurotransmission. Our goal is to reveal the molecular mechanisms of …
Delayed impact of 2-oxoadipate dehydrogenase inhibition on the rat brain metabolism is linked to protein glutarylation
AI Boyko, IS Karlina, LG Zavileyskiy, VA Aleshin… - Frontiers in …, 2022 - frontiersin.org
Background The DHTKD1-encoded 2-oxoadipate dehydrogenase (OADH) oxidizes 2-
oxoadipate—a common intermediate of the lysine and tryptophan catabolism. The mostly …
oxoadipate—a common intermediate of the lysine and tryptophan catabolism. The mostly …
Posttranslational Acylations of the Rat Brain Transketolase Discriminate the Enzyme Responses to Inhibitors of ThDP-Dependent Enzymes or Thiamine Transport
VA Aleshin, T Kaehne, MV Maslova, AV Graf… - International Journal of …, 2024 - mdpi.com
Transketolase (TKT) is an essential thiamine diphosphate (ThDP)-dependent enzyme of the
non-oxidative branch of the pentose phosphate pathway, with the glucose-6P flux through …
non-oxidative branch of the pentose phosphate pathway, with the glucose-6P flux through …
Phosphonate inhibitors of pyruvate dehydrogenase perturb homeostasis of amino acids and protein succinylation in the brain
AV Artiukhov, VA Aleshin, IS Karlina… - International Journal of …, 2022 - mdpi.com
Mitochondrial pyruvate dehydrogenase complex (PDHC) is essential for brain glucose and
neurotransmitter metabolism, which is dysregulated in many pathologies. Using specific …
neurotransmitter metabolism, which is dysregulated in many pathologies. Using specific …
Administration of Phosphonate Inhibitors of Dehydrogenases of 2-Oxoglutarate and 2-Oxoadipate to Rats Elicits Target-Specific Metabolic and Physiological …
VI Bunik, AV Artiukhov, AV Kazantsev… - Frontiers in …, 2022 - frontiersin.org
In vitro and in cell cultures, succinyl phosphonate (SP) and adipoyl phosphonate (AP)
selectively target dehydrogenases of 2-oxoglutarate (OGDH, encoded by OGDH/OGDHL) …
selectively target dehydrogenases of 2-oxoglutarate (OGDH, encoded by OGDH/OGDHL) …