[HTML][HTML] Integrated data envelopment analysis, multi-criteria decision making, and cluster analysis methods: Trends and perspectives

MS de Oliveira, V Steffen, AC de Francisco… - Decision Analytics …, 2023 - Elsevier
Abstract Data Envelopment Analysis (DEA), Multi-criteria Decision Analysis (MCDA), and
Cluster Analysis (CA) are techniques widely used to help decision-makers determine the …

Dysregulation of RNA splicing in early non-alcoholic fatty liver disease through hepatocellular carcinoma

NJG Webster, D Kumar, P Wu - Scientific Reports, 2024 - nature.com
While changes in RNA splicing have been extensively studied in hepatocellular carcinoma
(HCC), no studies have systematically investigated changes in RNA splicing during earlier …

Hepatocyte deletion of IGF2 prevents DNA damage and tumor formation in hepatocellular carcinoma

D Kumar, M Das, A Oberg, D Sahoo, P Wu… - Advanced …, 2022 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Serine‐
arginine rich splicing factor 3 (SRSF3) plays a critical role in hepatocyte function and its loss …

CFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis

S Ghosh, M Ataman, M Bak, A Börsch… - Nucleic acids …, 2022 - academic.oup.com
The mammalian cleavage factor I (CFIm) has been implicated in alternative polyadenylation
(APA) in a broad range of contexts, from cancers to learning deficits and parasite infections …

Immunological significance of prognostic alternative splicing signature in hepatocellular carcinoma

Q Xu, H Xu, R Deng, N Li, R Mu, Z Qi, Y Shen… - Cancer cell …, 2021 - Springer
Background Hepatocellular carcinoma (HCC) ranks the sixth prevalent tumors with high
mortality globally. Alternative splicing (AS) drives protein diversity, the imbalance of which …

Comprehensive analysis and establishment of a prediction model of alternative splicing events reveal the prognostic predictor and immune microenvironment …

S Yu, C Hu, L Liu, L Cai, X Du, Q Yu, F Lin… - Journal of Translational …, 2020 - Springer
Background Triple-negative breast cancer (TNBC) is widely concerning because of high
malignancy and poor prognosis. There is increasing evidence that alternative splicing (AS) …

[HTML][HTML] Integrative analysis identifies key mRNA biomarkers for diagnosis, prognosis, and therapeutic targets of HCV-associated hepatocellular carcinoma

Y Zhang, Y Tang, C Guo, G Li - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Hepatitis C virus-associated HCC (HCV-HCC) is a prevalent malignancy worldwide and the
molecular mechanisms are still elusive. Here, we screened 240 differentially expressed …

[HTML][HTML] A comprehensive characterization of alternative splicing events related to prognosis and the tumor microenvironment in lung adenocarcinoma

S Ma, J Zhu, M Wang, T Han, J Zhu… - Annals of Translational …, 2022 - ncbi.nlm.nih.gov
Background Alternative splicing (AS) is a critical mechanism of post-transcriptional
regulation and has been widely reported to be associated with the tumor progression and …

A novel 16-gene alternative mRNA splicing signature predicts tumor relapse and indicates immune activity in stage I–III hepatocellular carcinoma

XX Chen, BH Zhang, YC Lu, ZQ Li, CY Chen… - Frontiers in …, 2022 - frontiersin.org
Background: Hepatocellular carcinoma (HCC) is a lethal disease with high relapse and
dismal survival rates. Alternative splicing (AS) plays a crucial role in tumor progression …

A systems biology‐based approach to screen key splicing factors in hepatocellular carcinoma

R Zhu, X Wang, Q Yu, W Guo… - Molecular Carcinogenesis, 2023 - Wiley Online Library
A splicing factor is as an important upstream regulator of the alternative splicing process.
Hence, it is considered to be a therapeutic target for hepatocellular carcinoma (HCC) …