Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols

Q Jin, T Liu, Y Qiao, D Liu, L Yang, H Mao… - Frontiers in …, 2023 - frontiersin.org
Diabetic nephropathy (DN) often leads to end-stage renal disease. Oxidative stress
demonstrates a crucial act in the onset and progression of DN, which triggers various …

A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis

ZL Wang, S Wang, Y Kuang, ZM Hu, X Qiao… - Pharmaceutical …, 2018 - Taylor & Francis
Abstract Context: Scutellaria baicalensis Georgi (Lamiaceae) is a popular medicinal plant.
Its roots are used as the famous traditional Chinese medicine Huang-Qin, which is recorded …

Baicalin mitigates cognitive impairment and protects neurons from microglia‐mediated neuroinflammation via suppressing NLRP 3 inflammasomes and TLR 4/NF‐κB …

X Jin, MY Liu, DF Zhang, X Zhong, K Du… - CNS Neuroscience …, 2019 - Wiley Online Library
Aims Baicalin (BAI), a flavonoid compound isolated from the root of Scutellaria baicalensis
Georgi, has been established to have potent anti‐inflammation and neuroprotective …

Effects of natural antioxidants in neurodegenerative disease

SL Albarracin, B Stab, Z Casas, JJ Sutachan… - Nutritional …, 2012 - Taylor & Francis
Polyphenols are secondary metabolites with antioxidant properties and are abundant in the
diet. Fruits, vegetables, herbs, and various drinks (tea, wine, and juices) are all sources of …

Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives

A Melo, L Monteiro, RMF Lima… - Oxidative medicine …, 2011 - Wiley Online Library
The incidence and prevalence of neurodegenerative diseases (ND) increase with life
expectancy. This paper reviews the role of oxidative stress (OS) in ND and pharmacological …

Pharmacological effects of active components of Chinese herbal medicine in the treatment of Alzheimer's disease: a review

ZY Wang, JG Liu, H Li, HM Yang - The American Journal of Chinese …, 2016 - World Scientific
Alzheimer's disease (AD), the most common neurodegenerative disorder associated with
dementia, not only severely decreases the quality of life for its victims, but also brings a …

Inhibiting toxic aggregation of amyloidogenic proteins: a therapeutic strategy for protein misfolding diseases

B Cheng, H Gong, H Xiao, RB Petersen… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Background The deposition of self-assembled amyloidogenic proteins is associated with
multiple diseases, including Alzheimer's disease, Parkinson's disease and type 2 diabetes …

Neuroprotective and cognitive enhancement potentials of baicalin: a review

K Sowndhararajan, P Deepa, M Kim, SJ Park, S Kim - Brain Sciences, 2018 - mdpi.com
Neurodegenerative diseases are a heterogeneous group of disorders that are characterized
by the gradual loss of neurons. The development of effective neuroprotective agents to …

Dietary plant polyphenols as the potential drugs in neurodegenerative diseases: current evidence, advances, and opportunities

L Yan, MS Guo, Y Zhang, L Yu, JM Wu… - Oxidative Medicine …, 2022 - Wiley Online Library
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
and Huntington's disease (HD), are characterized by the progressive degeneration of …

Cocrystals of baicalein with higher solubility and enhanced bioavailability

B Zhu, Q Zhang, JR Wang, X Mei - Crystal Growth & Design, 2017 - ACS Publications
Baicalein (Bai) is one of the most important bioactive flavonoids isolated from the well-
known traditional Chinese medicine called “Huang Qin”. Though it has broad therapeutic …