Cytokines are critical mediators that oversee and regulate immune and inflammatory
responses via complex networks and serve as biomarkers for many diseases. Quantification …

Primary biliary cholangitis is an autoimmune liver disease that predominantly affects women.
It is characterised by a chronic and destructive, small bile duct, granulomatous lymphocytic …

Primary biliary cholangitis is a chronic, seropositive and female-predominant inflammatory
and cholestatic liver disease, which has a variable rate of progression towards biliary …

Autoimmune cholestatic liver diseases, including primary biliary cholangitis (PBC) and
primary sclerosing cholangitis (PSC), are manifested as an impairment of normal bile flow …

Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …

Interferon γ (IFNγ) is a pleiotropic protein secreted by immune cells. IFNγ signals through the
IFNγ receptor, a protein complex that mediates downstream signaling events. Studies into …

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by
autoimmune destruction of small to medium size intrahepatic bile ducts. The etiology of PBC …

Immune cell activation is a stringently regulated process, as exaggerated innate and
adaptive immune responses can lead to autoinflammatory and autoimmune diseases …

Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by biliary
destruction, progressive cholestasis, and potentially liver cirrhosis. Patients develop a well …

Peptide-major histocompatibility complex class II (pMHCII)-based nanomedicines displaying
tissue-specific autoantigenic epitopes can blunt specific autoimmune conditions by re …