Pathophysiology of CD4+ T-cell depletion in HIV-1 and HIV-2 infections
KK Vidya Vijayan, KP Karthigeyan, SP Tripathi… - Frontiers in …, 2017 - frontiersin.org
The hall mark of human immunodeficiency virus (HIV) infection is a gradual loss of CD4+ T-
cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity …
cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity …
Perspectives on the basic reproductive ratio
JM Heffernan, RJ Smith… - Journal of the Royal …, 2005 - royalsocietypublishing.org
The basic reproductive ratio, R 0, is defined as the expected number of secondary infections
arising from a single individual during his or her entire infectious period, in a population of …
arising from a single individual during his or her entire infectious period, in a population of …
Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
The viral reservoir represents a critical challenge for human immunodeficiency virus type 1
(HIV-1) eradication strategies,,,,. However, it remains unclear when and where the viral …
(HIV-1) eradication strategies,,,,. However, it remains unclear when and where the viral …
[图书][B] Stochastic epidemic models with inference
The aim of these Notes is to increase the reader's understanding of the spread of infectious
diseases using mathematics, and in particular stochastic methods. Needless to say …
diseases using mathematics, and in particular stochastic methods. Needless to say …
Computational immunology meets bioinformatics: the use of prediction tools for molecular binding in the simulation of the immune system
We present a new approach to the study of the immune system that combines techniques of
systems biology with information provided by data-driven prediction methods. To this end …
systems biology with information provided by data-driven prediction methods. To this end …
Modeling the mechanics of viral kinetics under immune control during primary infection of HIV-1 with treatment in fractional order
PA Naik, J Zu, KM Owolabi - Physica A: statistical mechanics and its …, 2020 - Elsevier
In this paper, we propose and analyze a fractional order model of viral kinetics for primary
infection of HIV-1 in presence of immune control with treatment, as the classical model of …
infection of HIV-1 in presence of immune control with treatment, as the classical model of …
Modeling the within-host dynamics of HIV infection
AS Perelson, RM Ribeiro - BMC biology, 2013 - Springer
The new field of viral dynamics, based on within-host modeling of viral infections, began with
models of human immunodeficiency virus (HIV), but now includes many viral infections …
models of human immunodeficiency virus (HIV), but now includes many viral infections …
The dynamics of CD4+ T-cell depletion in HIV disease
JM McCune - Nature, 2001 - nature.com
The size and composition of the CD4+ T-cell population is regulated by balanced
proliferation of progenitor cells and death of mature progeny. After infection with the human …
proliferation of progenitor cells and death of mature progeny. After infection with the human …
Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy
T Pierson, J McArthur… - Annual review of …, 2000 - annualreviews.org
The success of combination antiretroviral therapy for HIV-1 infection has generated interest
in mechanisms by which the virus can persist in the body despite the presence of drugs that …
in mechanisms by which the virus can persist in the body despite the presence of drugs that …