Understanding the DNA double-strand break repair and its therapeutic implications
U Ray, SC Raghavan - DNA repair, 2021 - Elsevier
Repair of DNA double-strand breaks (DSBs) and its regulation are tightly integrated inside
cells. Homologous recombination, nonhomologous end joining and microhomology …
cells. Homologous recombination, nonhomologous end joining and microhomology …
Challenges of gene editing therapies for genodermatoses
IR Brooks, A Sheriff, D Moran, J Wang… - International Journal of …, 2023 - mdpi.com
Genodermatoses encompass a wide range of inherited skin diseases, many of which are
monogenic. Genodermatoses range in severity and result in early-onset cancers or life …
monogenic. Genodermatoses range in severity and result in early-onset cancers or life …
Double‐strand DNA break repair: molecular mechanisms and therapeutic targets
J Tan, X Sun, H Zhao, H Guan, S Gao, PK Zhou - MedComm, 2023 - Wiley Online Library
Abstract Double‐strand break (DSB), a significant DNA damage brought on by ionizing
radiation, acts as an initiating signal in tumor radiotherapy, causing cancer cells death. The …
radiation, acts as an initiating signal in tumor radiotherapy, causing cancer cells death. The …
Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics
N Kumari, H Antil, S Kumari, SC Raghavan - Genomics, 2023 - Elsevier
Ligase IV is a key enzyme involved during DNA double-strand breaks (DSBs) repair through
nonhomologous end joining (NHEJ). However, in contrast to Ligase IV deficient mouse cells …
nonhomologous end joining (NHEJ). However, in contrast to Ligase IV deficient mouse cells …
Identification and characterization of mercaptopyrimidine‐based small molecules as inhibitors of nonhomologous DNA end joining
Mercaptopyrimidine derivatives are heterocyclic compounds with potent biological activities
including antiproliferative, antibacterial, and anti‐inflammatory properties. The present study …
including antiproliferative, antibacterial, and anti‐inflammatory properties. The present study …
Exposure to endosulfan can cause long term effects on general biology, including the reproductive system of mice
Increased infertility in humans is attributed to the increased use of environmental chemicals
in the last several decades. Various studies have identified pesticides as one of the causes …
in the last several decades. Various studies have identified pesticides as one of the causes …
Design and Synthesis of Ketenimine Sulfonamide Conjugates through Multicomponent Reactions; A Combined Cytotoxic Analysis and Computational Exploration
Multicomponent reactions involving zwitterion generated from dimethyl
acetylenedicarboxylate, aryl sulfonamide, and isocyanide to generate sulfonamide …
acetylenedicarboxylate, aryl sulfonamide, and isocyanide to generate sulfonamide …
Microwave‐Assisted Synthesis and Characterization of Some Aldehyde Derivatives of Imidazo [2, 1‐b][1, 3, 4] thiadiazole: Crystal Structure Insights, In‐Silico and …
The microwave‐assisted synthesis, crystallographic studies, in‐silico docking and the
evaluation of in‐vitro biological activities of 2‐(3, 4‐dimethoxy)‐6‐(substituted phenyl) …
evaluation of in‐vitro biological activities of 2‐(3, 4‐dimethoxy)‐6‐(substituted phenyl) …
[PDF][PDF] 靶向DNA 损伤应答在肿瘤放射增敏治疗的研究进展
李明君， 李佳霖， 杨波 - 中国比较医学杂志, 2023 - zgbjyx.cnjournals.com
放射治疗是恶性肿瘤治疗的重要手段, 但是, 肿瘤放射抗拒是限制放疗疗效, 肿瘤复发转移的主要
因素. 在DNA 受损的情况下, 细胞内DNA 损伤应答随之被激活. 研究发现DNA …
因素. 在DNA 受损的情况下, 细胞内DNA 损伤应答随之被激活. 研究发现DNA …
Radioresistance and radiosensitization in high-risk Group 3 pediatric medulloblastoma
E Hawkins - 2023 - theses.hal.science
Medulloblastoma (MB) is the most common pediatric malignant brain tumour, and is treated
with a multimodal regimen of surgical resection, chemotherapy, and radiotherapy …
with a multimodal regimen of surgical resection, chemotherapy, and radiotherapy …