Spinal muscular atrophy (SMA) is a devastating childhood motor neuron disease that, in the
most severe cases and when left untreated, leads to death within the first two years of life …

Ever since loss of survival motor neuron (SMN) protein was identified as the direct cause of
the childhood inherited neurodegenerative disorder spinal muscular atrophy, significant …

In autophagy long‐lived proteins, protein aggregates or damaged organelles are engulfed
by vesicles called autophagosomes prior to lysosomal degradation. Autophagy dysfunction …

With global population aging, age-related diseases, especially sarcopenia, have attracted
much attention in recent years. Characterized by low muscle strength, low muscle quantity or …

Although denervated muscle atrophy is common, the underlying molecular mechanism
remains unelucidated. We have previously found that oxidative stress and inflammatory …

Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder caused by
recessive mutations in the SMN1 gene, globally affecting~ 8–14 newborns per 100,000. The …

Spinal muscular atrophy (SMA) is the most common genetic disease affecting infants and
young adults. Due to mutation/deletion of the survival motor neuron (SMN) gene, SMA is …

Reduced expression of the survival motor neuron (SMN) protein causes the
neurodegenerative disease spinal muscular atrophy (SMA). Here, we show that adeno …

Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease of variable
clinical severity that is caused by mutations in the survival motor neuron 1 (SMN1) gene …

Intracerebral transplantation of neural stem cells (NSCs) for ischemic stroke treatment has
been demonstrated to be inefficient, with only< 5% of delivered cells being retained …