The endocannabinoid system is up-regulated in numerous pathophysiological states such
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …

Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease”
electing multitarget compounds as potential therapeutic tools suitable for the treatment of …

9H-carbazole is an aromatic molecule that is tricyclic in nature, with two benzene rings fused
onto a 5-membered pyrrole ring. Obtained from natural sources or by synthetic routes, this …

The endocannabinoid system consists of cannabinoid CB1 and CB2 receptors, of
endogenous agonists for these receptors known as 'endocannabinoids', and of processes …

Herein, we report a facile and efficient synthetic method to construct azepino [1, 2-a] indoles
through a novel gold (I)-catalyzed intramolecular hydroarylation of alkynylindoles. A wide …

We have described a dual palladium-photoredox-catalyzed highly regioselective acylation
of carbazoles and indolines using molecular oxygen as the green oxidant. The reaction …

Alzheimer's disease (AD) is characterized by misfolding, oligomerization, and accumulation
of amyloid-β (Aβ) peptides in the brain. Aβ monomers transform into Aβ oligomers, which are …

Acute lung injury (ALI), characterized by a severe inflammatory process, is a complex
syndrome that can lead to multisystem organ failure. Fatty acid amide hydrolase (FAAH) and …

The ability of nonsteroidal anti-inflammatory drugs (NSAIDs) to inhibit cyclooxygenase (Cox)-
1 and Cox-2 underlies the therapeutic efficacy of these drugs, as well as their propensity to …

Indole structural motifs are ubiquitous in natural products, pharmaceuticals, agrochemicals
and functional materials. The immense importance of the indole moiety, especially in the …