• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

The microbiology, epidemiology, diagnostics, and treatment of infective endocarditis (IE)
have changed significantly since the Duke Criteria were published in 1994 and modified in …

Infective endocarditis is a relatively rare, but deadly cause of sepsis, with an overall mortality
ranging from 20 to 25% in most series. Although the classic clinical classification into …

Infective endocarditis (IE) is a rare but potentially life-threatening disease, sometimes with
longstanding sequels among surviving patients. The population at high risk of IE is …

A positive follow-up blood culture for methicillin-resistant Staphylococcus aureus (MRSA)
while on seemingly appropriate therapy is a common and ominous development. However …

Methicillin-resistant Staphylococcus aureus (MRSA) is a devastating pathogen responsible
for a variety of life-threatening infections. A distinctive characteristic of this pathogen is its …

Staphylococcus aureus bacteremia (SAB) carries a high risk for excess morbidity and
mortality. Despite its prevalence, significant practice variation continues to permeate clinical …

Infective endocarditis (IE) is a life-threatening microbial infection of native and prosthetic
heart valves, endocardial surface, and/or indwelling cardiac device. Prevalence of IE is …

Background Despite being the leading cause of mortality from bloodstream infections
worldwide, little is known about regional variation in treatment practices for Staphylococcus …

Imaging is an important tool in the diagnosis and management of infective endocarditis (IE).
Echocardiography is an essential examination, especially in native valve endocarditis …