Brain metastases are a very common manifestation of cancer that have historically been
approached as a single disease entity given the uniform association with poor clinical …

Brain metastases occur commonly in patients with advanced solid malignancies. Yet, less is
known about brain metastases than cancer-related entities of similar incidence. Advances in …

PURPOSE Radiation dose to the neuroregenerative zone of the hippocampus has been
found to be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity …

Background Whole brain radiotherapy (WBRT) is the standard of care to improve intracranial
control following resection of brain metastasis. However, stereotactic radiosurgery (SRS) to …

Importance Whole brain radiotherapy (WBRT) significantly improves tumor control in the
brain after stereotactic radiosurgery (SRS), yet because of its association with cognitive …

Reactive oxygen species (ROS) plays a key role in therapeutic effects as well as side effects
of platinum drugs. Cisplatin mediates activation of nicotinamide adenine dinucleotide …

Background To determine the protective effects of memantine on cognitive function in
patients receiving whole-brain radiotherapy (WBRT). Methods Adult patients with brain …

This brief review explores the areas of cognitive impairment that have been observed in
cancer patients and survivors, the cognitive assessment tools used, and the management of …

Background Approximately 50% of newly diagnosed glioblastomas (GBMs) harbor
epidermal growth factor receptor gene amplification (EGFR-amp). Preclinical and early …

PURPOSE: Controversy endures regarding the optimal treatment of patients with brain
metastases (BMs). Debate persists, despite many randomized trials, perhaps because BM …