Mitochondrial dysfunction, oxidative stress, and neuroinflammation: Intertwined roads to neurodegeneration
Oxidative stress develops as a response to injury and reflects a breach in the cell's
antioxidant capacity. Therefore, the fine-tuning of reactive oxygen species (ROS) generation …
antioxidant capacity. Therefore, the fine-tuning of reactive oxygen species (ROS) generation …
Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF
R Fischer, O Maier - Oxidative medicine and cellular longevity, 2015 - Wiley Online Library
Neuroinflammation and mitochondrial dysfunction are common features of chronic
neurodegenerative diseases of the central nervous system. Both conditions can lead to …
neurodegenerative diseases of the central nervous system. Both conditions can lead to …
The role of oxidative stress in Parkinson's disease
V Dias, E Junn, MM Mouradian - Journal of Parkinson's …, 2013 - content.iospress.com
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
AHV Schapira - The Lancet Neurology, 2008 - thelancet.com
Several biochemical abnormalities have been described in the brains of patients with
Parkinson's disease (PD), including oxidative stress and mitochondrial dysfunction. The …
Parkinson's disease (PD), including oxidative stress and mitochondrial dysfunction. The …
Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
Alpha-synuclein is the major protein component of Lewy bodies, a cardinal pathological
feature of the degenerating Parkinsonian brain. Alpha-synuclein has been reported to be …
feature of the degenerating Parkinsonian brain. Alpha-synuclein has been reported to be …
Redox imbalance in Parkinson's disease
SJ Chinta, JK Andersen - Biochimica et Biophysica Acta (BBA)-General …, 2008 - Elsevier
Parkinson's disease (PD) is an adult-onset neurodegenerative disorder characterized by
preferential loss of dopaminergic neurons in an area of the midbrain called the substantia …
preferential loss of dopaminergic neurons in an area of the midbrain called the substantia …
Localization of α-synuclein to mitochondria within midbrain of mice
WW Li, R Yang, JC Guo, HM Ren, XL Zha… - …, 2007 - journals.lww.com
The interrelationship between α-synuclein (α-syn) and mitochondria is not clearly
understood. Owing to the lack of the signal peptide and its predominant localization in the …
understood. Owing to the lack of the signal peptide and its predominant localization in the …
[HTML][HTML] Emerging pathways to neurodegeneration: Dissecting the critical molecular mechanisms in Alzheimer's disease, Parkinson's disease
SH Tan, V Karri, NWR Tay, KH Chang, HY Ah… - Biomedicine & …, 2019 - Elsevier
Neurodegenerative diseases are usually sporadic in nature and commonly influenced by a
wide range of genetic, life style and environmental factors. A unifying feature of Alzheimer's …
wide range of genetic, life style and environmental factors. A unifying feature of Alzheimer's …
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease
M Oñate, A Catenaccio, N Salvadores… - Cell Death & …, 2020 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative condition,
characterized by motor impairment due to the progressive degeneration of dopaminergic …
characterized by motor impairment due to the progressive degeneration of dopaminergic …
Mice lacking alpha-synuclein are resistant to mitochondrial toxins
P Klivenyi, D Siwek, G Gardian, L Yang, A Starkov… - Neurobiology of …, 2006 - Elsevier
Abnormalities in the function of α-synuclein are implicated in the pathogenesis of
Parkinson's disease (PD). We found that α-synuclein-deficient mice are resistant to MPTP …
Parkinson's disease (PD). We found that α-synuclein-deficient mice are resistant to MPTP …