Oxidative stress develops as a response to injury and reflects a breach in the cell's
antioxidant capacity. Therefore, the fine-tuning of reactive oxygen species (ROS) generation …

Neuroinflammation and mitochondrial dysfunction are common features of chronic
neurodegenerative diseases of the central nervous system. Both conditions can lead to …

Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

Several biochemical abnormalities have been described in the brains of patients with
Parkinson's disease (PD), including oxidative stress and mitochondrial dysfunction. The …

Alpha-synuclein is the major protein component of Lewy bodies, a cardinal pathological
feature of the degenerating Parkinsonian brain. Alpha-synuclein has been reported to be …

Parkinson's disease (PD) is an adult-onset neurodegenerative disorder characterized by
preferential loss of dopaminergic neurons in an area of the midbrain called the substantia …

The interrelationship between α-synuclein (α-syn) and mitochondria is not clearly
understood. Owing to the lack of the signal peptide and its predominant localization in the …

Neurodegenerative diseases are usually sporadic in nature and commonly influenced by a
wide range of genetic, life style and environmental factors. A unifying feature of Alzheimer's …

Parkinson's disease (PD) is the second most common neurodegenerative condition,
characterized by motor impairment due to the progressive degeneration of dopaminergic …

Abnormalities in the function of α-synuclein are implicated in the pathogenesis of
Parkinson's disease (PD). We found that α-synuclein-deficient mice are resistant to MPTP …