The factor H (FH) protein family is emerging as a complex network of proteins controlling the
fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range …

The complement system, while being an essential and very efficient effector component of
innate immunity, may cause damage to the host and result in various inflammatory …

Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly
population. A strong effect on AMD risk has been reported for genetic variants at the CFH …

Inflammation is a common denominator of diseases. The complement system, an intrinsic
part of the innate immune system, is a key driver of inflammation in numerous disorders …

The alternative pathway is a continuously active surveillance arm of the complement system,
and it can also enhance complement activation initiated by the classical and the lectin …

Dysregulation of the alternative pathway (AP) of the complement system is a significant
contributor to age-related macular degeneration (AMD), a primary cause of irreversible …

Complement is an ancient and complex network of the immune system and, as such, it plays
vital physiological roles, but it is also involved in numerous pathological processes. The …

After years of disappointing clinical results, the tide has finally changed and complement
targeted-therapies have become a validated and accepted treatment option for several …

Neisseria meningitidis and Neisseria gonorrhoeae are important human pathogens that
have evolved to bind the major negative regulator of the complement system, complement …

Directing selective complement activation towards tumour cells is an attractive strategy to
promote their elimination. In the present work, we have generated heteromultimeric …