The complexity of glioblastoma multiforme, the most common and lethal variant of gliomas,
is reflected by cellular and molecular heterogeneity at both the inter-and intra-tumoural …

The heterogeneous expression of tumor-associated antigens limits the efficacy of chimeric
antigen receptor (CAR)–redirected T cells (CAR-Ts) for the treatment of glioblastoma (GBM) …

Glioblastoma (GBM) is known as an intractable, highly heterogeneous tumor encompassing
multiple subclones, each supported by a distinct glioblastoma stem cell (GSC). The …

In glioma patients, high levels of glutamate can cause brain edema and seizures. GLAST, a
glutamate–aspartate transporter expressed by astrocytes with a role in glutamate uptake, is …

During surgical procedures for gliomas, tissue material obtained from cavitational ultrasonic
surgical aspirators (CUSAs) is generally discarded but can actually exceed the amount and …

Adult neural progenitor cells (aNPCs) are a potential source for cell based therapy for
neurodegenerative diseases and traumatic brain injuries. These cells have been …

Modern neurosurgery strives to maximize tumor removal while preserving healthy tissue
integrity. Accurate intraoperative differentiation between tumor and healthy tissue is crucial …

Background Vestibular schwannoma (VS) is a benign tumor arising from the Schwann cells
of the eighth cranial nerve. The complexity in treatment is associated with unpredictable …

Non-canonical tumor-specific antigens (ncTSAs) can expand the pool of targets for cancer
immunotherapy, but require robust and comprehensive computational pipelines for their …

Cultures enriched in glioblastoma stem-like cells (GSCs) are prominent in vitro models to
investigate molecular determinants and therapeutic targets of glioblastoma; however …