The soy phytoestrogen, genistein, induces thymic atrophy when administered to
ovariectomized mice by injection or in the diet. Injected genistein also causes decreased …

This review will describe the SH2-domain signaling protein Src Homology-2 domain
containing protein B (SHB) and its role in various physiological processes relating in …

Focal adhesion kinase (FAK) is essential for vascular endothelial growth factor-A
(VEGFA)/VEGF receptor-2 (VEGFR2)-stimulated angiogenesis and vascular permeability …

Replicative cellular senescence is the main cause of aging. It is important to note that early
senescence is linked to tissue regeneration, whereas late senescence is known to trigger a …

Background Shb is a signaling protein downstream of vascular endothelial growth factor
receptor-2 and Shb deficiency has been found to restrict tumor angiogenesis. The present …

Abstract Background The Src homology-2 domain protein B (Shb) is an adapter protein
operating downstream of several tyrosine kinase receptors and consequently Shb regulates …

The tamoxifen-responsive conditional Cdh5-CreERT2 is commonly used for endothelial cell
specific conditional deletion of loxP-flanked gene sequences. To address the role of …

The mouse Shb gene coding for the Src Homology 2-domain containing adapter protein B
has recently been placed in context of BCRABL1-induced myeloid leukemia in mice and the …

Aim Myeloid cells have been suggested to participate in angiogenesis and regulation of
vascular function. Shb‐deficient mice display both vascular and myeloid cell abnormalities …

To assess mechanisms responsible for breast carcinoma metastasis, 4T1 breast carcinomas
were grown orthotopically in wild type or Shb knockout mice. Tumor growth, metastasis …