Magnesium: biochemistry, nutrition, detection, and social impact of diseases linked to its deficiency

D Fiorentini, C Cappadone, G Farruggia, C Prata - Nutrients, 2021 - mdpi.com
Magnesium plays an important role in many physiological functions. Habitually low intakes
of magnesium and in general the deficiency of this micronutrient induce changes in …

Utilizing synchrotron radiation for the characterization of biodegradable magnesium alloys—from alloy development to the application as implant material

B Zeller-Plumhoff, D Tolnai, M Wolff… - Advanced …, 2021 - Wiley Online Library
Magnesium alloys are highly attractive for their application as structural materials as well as
medical implants. A range of alloying systems exists which are investigated, eg, in terms of …

Soft X-ray microscopy radiation damage on fixed cells investigated with synchrotron radiation FTIR microscopy

A Gianoncelli, L Vaccari, G Kourousias, D Cassese… - Scientific reports, 2015 - nature.com
Radiation damage of biological samples remains a limiting factor in high resolution X-ray
microscopy (XRM). Several studies have attempted to evaluate the extent and the effects of …

Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach

MAK Azad, KD Roberts, HH Yu, B Liu… - Analytical …, 2015 - ACS Publications
Polymyxin is the last-line therapy against Gram-negative 'superbugs'; however, dose-limiting
nephrotoxicity can occur in up to 60% of patients after intravenous administration …

[HTML][HTML] Overview of chemical imaging methods to address biological questions

MML da Cunha, S Trepout, C Messaoudi, TD Wu… - Micron, 2016 - Elsevier
Chemical imaging offers extensive possibilities for better understanding of biological
systems by allowing the identification of chemical components at the tissue, cellular, and …

Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin

S Castiglioni, A Cazzaniga, V Trapani, C Cappadone… - Scientific reports, 2015 - nature.com
Neoplastic cells accumulate magnesium, an event which provides selective advantages and
is frequently associated with TRPM7overexpression. Little is known about magnesium …

Overexpression of the mitochondrial Mg channel MRS2 increases total cellular Mg concentration and influences sensitivity to apoptosis

L Merolle, G Sponder, A Sargenti, L Mastrototaro… - Metallomics, 2018 - academic.oup.com
The mechanism of action of the mitochondrial Mg channel MRS2 and its involvement in cell
viability remain unclear. Deletion of MRS2 has been reported to abolish Mg influx into …

Combined micro-XRF and TXRF methodology for quantitative elemental imaging of tissue samples

PM Wróbel, S Bała, M Czyzycki, M Golasik, T Librowski… - Talanta, 2017 - Elsevier
Local differences in structural properties of biological specimens pose a major limitation to
quantitative X-ray fluorescence imaging. This is because both the various tissue …

Reconstruction of 3D topographic landscape in soft X-ray fluorescence microscopy through an inverse X-ray-tracing approach based on multiple detectors

M Ippoliti, F Billè, AG Karydas, A Gianoncelli… - Scientific Reports, 2022 - nature.com
The study of X-ray fluorescence (XRF) emission spectra is a powerful technique used in
applications that range from biology to cultural heritage. Key objectives of this technique …

3D quantitative and ultrastructural analysis of mitochondria in a model of doxorubicin sensitive and resistant human colon carcinoma cells

C Moscheni, E Malucelli, S Castiglioni, A Procopio… - Cancers, 2019 - mdpi.com
Drug resistance remains a major obstacle in cancer treatment. Because mitochondria
mediate metabolic reprogramming in cancer drug resistance, we focused on these …