Importance Despite discrete etiologies leading to delirium, it is treated as a common end
point in hospital and in clinical trials, and delirium research may be hampered by the attempt …

Delirium and dementia are two of the most common causes of cognitive impairment in older
populations, yet their interrelation remains poorly understood. Previous studies have shown …

Immune molecules such as cytokines and chemokines and the cells that produce them
within the brain, notably microglia, are critical for normal brain development. This recognition …

Here, we identified release of extracellular vesicles (EVs) by the choroid plexus epithelium
(CPE) as a new mechanism of blood–brain communication. Systemic inflammation induced …

Background: Delirium occurs commonly in hospitalized older patients but is poorly
recognized. Although there are a plethora of validated delirium screening tools, it is unclear …

Background Guidelines suggest limited and cautious use of antipsychotics for treatment of
delirium where nonpharmacological interventions have failed and symptoms remain …

Challenges and opportunities in understanding dementia and delirium in the acute hospital |
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Background Delirium is a profound neuropsychiatric disturbance precipitated by acute
illness. Although dementia is the major risk factor this has typically been considered a binary …

Delirium is characterized by an acutely altered mental status accompanied by reductions in
cognitive function and attention. Delirium in septic patients, termed sepsis-associated …

Delirium is a frequent neurocognitive complication in patients with cancer, particularly in
patients with advanced-stage disease (in whom a combination of factors might trigger an …