Harnessing deep learning for population genetic inference
In population genetics, the emergence of large-scale genomic data for various species and
populations has provided new opportunities to understand the evolutionary forces that drive …
populations has provided new opportunities to understand the evolutionary forces that drive …
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
Shaping immunity: The influence of natural selection on population immune diversity
Humans exhibit considerable variability in their immune responses to the same immune
challenges. Such variation is widespread and affects individual and population‐level …
challenges. Such variation is widespread and affects individual and population‐level …
[HTML][HTML] A genome resource for green millet Setaria viridis enables discovery of agronomically valuable loci
Wild and weedy relatives of domesticated crops harbor genetic variants that can advance
agricultural biotechnology. Here we provide a genome resource for the wild plant green …
agricultural biotechnology. Here we provide a genome resource for the wild plant green …
rehh 2.0: a reimplementation of the R package rehh to detect positive selection from haplotype structure
Identifying genomic regions with unusually high local haplotype homozygosity represents a
powerful strategy to characterize candidate genes responding to natural or artificial positive …
powerful strategy to characterize candidate genes responding to natural or artificial positive …
[HTML][HTML] An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia
The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
emphasized the vulnerability of human populations to novel viral pressures, despite the vast …
emphasized the vulnerability of human populations to novel viral pressures, despite the vast …
The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism
Cattle pastoralism plays a central role in human livelihood in Africa. However, the genetic
history of its success remains unknown. Here, through whole-genome sequence analysis of …
history of its success remains unknown. Here, through whole-genome sequence analysis of …
[HTML][HTML] Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication
More people globally depend on the water buffalo than any other domesticated species, and
as the most closely related domesticated species to cattle they can provide important …
as the most closely related domesticated species to cattle they can provide important …
Integrated environmental and genomic analysis reveals the drivers of local adaptation in African indigenous chickens
AA Gheyas, A Vallejo-Trujillo, A Kebede… - Molecular biology …, 2021 - academic.oup.com
Breeding for climate resilience is currently an important goal for sustainable livestock
production. Local adaptations exhibited by indigenous livestock allow investigating the …
production. Local adaptations exhibited by indigenous livestock allow investigating the …
[HTML][HTML] Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans
Abstract Background The 2'-5'oligoadenylate synthetase (OAS) locus encodes for three OAS
enzymes (OAS1-3) involved in innate immune response. This region harbors high amounts …
enzymes (OAS1-3) involved in innate immune response. This region harbors high amounts …