Two opposing models have been proposed to describe the function of the MYC oncoprotein
in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active …

The cellular stress response corresponds to the molecular changes that a cell undergoes in
response to various environmental stimuli. It induces drastic changes in the regulation of …

Chronic myeloid leukemia (CML) has been regarded as the paradigmatic example of a
malignancy defined by a unique molecular event, the BCR-ABL1 oncogene. Decades of …

Chronic myeloid leukaemia (CML) is a myeloproliferative disorder arising in the
haemopoietic stem cell (HSC) compartment. This disease is characterised by a reciprocal t …

The BCR-ABL1 oncoprotein transforms pluripotent HSCs and initiates chronic myeloid
leukemia (CML). Patients with early phase (also known as chronic phase [CP]) disease …

MicroRNAs and heterogeneous ribonucleoproteins (hnRNPs) are posttranscriptional gene
regulators that bind mRNA in a sequence-specific manner. Here, we report that loss of miR …

SR and hnRNP proteins were initially discovered as regulators of alternative splicing: the
process of controlled removal of introns and selective joining of exons through which …

Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that
evolve through a multi-step process. CML is also one of the best examples of a disease that …

Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an DNA/RNA‐binding protein and
regulates a wide range of biological processes and disease pathogenesis. It contains 3 K …

Tumor-associated alterations in RNA splicing result either from mutations in splicing-
regulatory elements or changes in components of the splicing machinery. This review …