In this critical review, the ring opening of non-activated 2-substituted aziridinesvia
intermediate aziridinium salts will be dealt with. Emphasis will be put on the relationship …

Although catalytic asymmetric synthesis has undergone tremendous growth in the last 30
years, chiral auxiliary-aided asymmetric synthesis continues to attract considerable …

This report details a general and enantioselective means for the synthesis of alkyl-
substituted aziridines. This protocol offers a direct route for the synthesis of alkyl-substituted …

A highly efficient and practical approach for the synthesis of optically pure β-amino alcohols
by the SmI2-induced reductive cross-coupling of chiral N-tert-butanesulfinyl imines with …

Collecting marine organisms for the discovery and development of pharmaceuticals has
been perceived variously as sustaining and threatening conservation. Our initial …

A new chiral aziridino alcohol ligand for zinc (II)-catalyzed azomethine ylide cycloadditions
is described. In the presence of this catalyst, N-arylidene glycine methyl esters react with a …

Sphingolipids are bio-active metabolites that show structural diversity among eukaryotes.
They are essential for growth of all eukaryotic cells but when produced in an uncontrolled …

A preparatively easy and efficient protocol for the resolution of racemic 2-aminocyclohexanol
derivatives is described, delivering both enantiomers with> 99% enantiomeric excess (ee) …

Two variations of the Overman rearrangement have been developed for the highly selective
synthesis of anti-vicinal amino alcohol natural products. A MOM ether-directed palladium (II) …

A stereoselective synthesis of spisulosine (ES285) and 4, 5-dehydrospisulosine
stereoisomers is described. Hydrozirconation of 1-pentadecyne with Schwartz reagent …