The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in
haematopoietic cells,. The JAK gene JAK2 is frequently mutated in the ageing …

Thrombotic, vascular, and bleeding complications are the most common causes of morbidity
and mortality in the Philadelphia chromosome–negative myeloproliferative neoplasms …

We investigated the neutrophil-to-lymphocyte ratio (NLR) as a predictor of thrombosis in
polycythemia vera (PV). After a median follow-up of 2.51 years, of 1508 PV patients enrolled …

Ischemic stroke has a high recurrence rate despite treatment. This underlines the
significance of investigating new possible cerebrovascular risk factors, such as the acquired …

Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene are often present in newly
diagnosed acute myeloid leukemia (AML) patients with an incidence rate of approximately …

RNA-binding proteins (RBPs) can recognize thousands of RNAs that help to maintain cell
homeostasis, and RBP dysfunction is frequently observed in various cancers. However …

Background Vascular activation is characterized by increased proinflammatory, pro
thrombotic, and proadhesive signaling. Several chronic and acute conditions, including Bcr …

Diabetic nephropathy (DN) is a renal complication of diabetic hyperglycemia. The Signal
transducer and activator of transcription 3 (Stat3) is a center molecule of the chronic …