[HTML][HTML] Alternative splicing in the mammalian nervous system: recent insights into mechanisms and functional roles
B Raj, BJ Blencowe - Neuron, 2015 - cell.com
High-throughput transcriptomic profiling approaches have revealed that alternative splicing
(AS) of precursor mRNAs, a fundamental process by which cells expand their transcriptomic …
(AS) of precursor mRNAs, a fundamental process by which cells expand their transcriptomic …
[HTML][HTML] Differential fates of introns in gene expression due to global alternative splicing
The discovery of introns over four decades ago revealed a new vision of genes and their
interrupted arrangement. Throughout the years, it has appeared that introns play essential …
interrupted arrangement. Throughout the years, it has appeared that introns play essential …
An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms
Alternative splicing (AS) generates remarkable regulatory and proteomic complexity in
metazoans. However, the functions of most AS events are not known, and programs of …
metazoans. However, the functions of most AS events are not known, and programs of …
Widespread intron retention in mammals functionally tunes transcriptomes
U Braunschweig, NL Barbosa-Morais, Q Pan… - Genome …, 2014 - genome.cshlp.org
Alternative splicing (AS) of precursor RNAs is responsible for greatly expanding the
regulatory and functional capacity of eukaryotic genomes. Of the different classes of AS …
regulatory and functional capacity of eukaryotic genomes. Of the different classes of AS …
[HTML][HTML] A highly conserved program of neuronal microexons is misregulated in autistic brains
Alternative splicing (AS) generates vast transcriptomic and proteomic complexity. However,
which of the myriad of detected AS events provide important biological functions is not well …
which of the myriad of detected AS events provide important biological functions is not well …
[HTML][HTML] Precise temporal regulation of alternative splicing during neural development
SM Weyn-Vanhentenryck, H Feng… - Nature …, 2018 - nature.com
Alternative splicing (AS) is one crucial step of gene expression that must be tightly regulated
during neurodevelopment. However, the precise timing of developmental splicing switches …
during neurodevelopment. However, the precise timing of developmental splicing switches …
[HTML][HTML] Coordinated splicing of regulatory detained introns within oncogenic transcripts creates an exploitable vulnerability in malignant glioma
Glioblastoma (GBM) is a devastating malignancy with few therapeutic options. We identify
PRMT5 in an in vivo GBM shRNA screen and show that PRMT5 knockdown or inhibition …
PRMT5 in an in vivo GBM shRNA screen and show that PRMT5 knockdown or inhibition …
Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform
T Gonatopoulos-Pournatzis, M Aregger… - Nature …, 2020 - nature.com
Systematic mapping of genetic interactions (GIs) and interrogation of the functions of sizable
genomic segments in mammalian cells represent important goals of biomedical research. To …
genomic segments in mammalian cells represent important goals of biomedical research. To …
[HTML][HTML] QAPA: a new method for the systematic analysis of alternative polyadenylation from RNA-seq data
Alternative polyadenylation (APA) affects most mammalian genes. The genome-wide
investigation of APA has been hampered by an inability to reliably profile it using …
investigation of APA has been hampered by an inability to reliably profile it using …
Dynamic regulation of RNA editing in human brain development and disease
RNA editing is increasingly recognized as a molecular mechanism regulating RNA activity
and recoding proteins. Here we surveyed the global landscape of RNA editing in human …
and recoding proteins. Here we surveyed the global landscape of RNA editing in human …