Protein kinase CK2: a potential therapeutic target for diverse human diseases
CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …
substrates, controls several signaling pathways, and is implicated in a plethora of human …
The mechanisms of Hedgehog signalling and its roles in development and disease
J Briscoe, PP Thérond - Nature reviews Molecular cell biology, 2013 - nature.com
The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …
decades ago inaugurated a field that has diversified to encompass embryonic development …
Hedgehog signaling mechanism and role in cancer
J Jiang - Seminars in cancer biology, 2022 - Elsevier
Cell-cell communication through evolutionarily conserved signaling pathways governs
embryonic development and adult tissue homeostasis. Deregulation of these signaling …
embryonic development and adult tissue homeostasis. Deregulation of these signaling …
The Hedgehog signal transduction network
Hedgehog (Hh) proteins regulate the development of a wide range of metazoan embryonic
and adult structures, and disruption of Hh signaling pathways results in various human …
and adult structures, and disruption of Hh signaling pathways results in various human …
Strategies of targeting CK2 in drug discovery: challenges, opportunities, and emerging prospects
Y Chen, Y Wang, J Wang, Z Zhou, S Cao… - Journal of Medicinal …, 2023 - ACS Publications
CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …
cells and plays important roles in a variety of cellular functions, including cell growth …
CK2 in cancer: cellular and biochemical mechanisms and potential therapeutic target
MMJ Chua, CE Ortega, A Sheikh, M Lee… - Pharmaceuticals, 2017 - mdpi.com
CK2 genes are overexpressed in many human cancers, and most often overexpression is
associated with worse prognosis. Site-specific expression in mice leads to cancer …
associated with worse prognosis. Site-specific expression in mice leads to cancer …
Decoding the phosphorylation code in Hedgehog signal transduction
Y Chen, J Jiang - Cell research, 2013 - nature.com
Hedgehog (Hh) signaling plays pivotal roles in embryonic development and adult tissue
homeostasis, and its deregulation leads to numerous human disorders including cancer …
homeostasis, and its deregulation leads to numerous human disorders including cancer …
Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma
A major limitation of targeted cancer therapy is the rapid emergence of drug resistance,
which often arises through mutations at or downstream of the drug target or through intrinsic …
which often arises through mutations at or downstream of the drug target or through intrinsic …
Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways
CK2 is a multitask kinase whose role is essential for a countless number of cellular
processes, many of which are critical for blood cell development. A prevailing task for this …
processes, many of which are critical for blood cell development. A prevailing task for this …
Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS
Backgound Amyotrophic lateral sclerosis (ALS) is progressive neurodegenerative disease
characterized by the loss of motor function. Several ALS genes have been identified as their …
characterized by the loss of motor function. Several ALS genes have been identified as their …