Advantages of genome sequencing by long-read sequencer using SMRT technology in medical area

K Nakano, A Shiroma, M Shimoji, H Tamotsu… - Human cell, 2017 - Springer
PacBio RS II is the first commercialized third-generation DNA sequencer able to sequence a
single molecule DNA in real-time without amplification. PacBio RS II's sequencing …

Systematic analysis of drug combinations against Gram-positive bacteria

E Cacace, V Kim, V Varik, M Knopp, M Tietgen… - Nature …, 2023 - nature.com
Drug combinations can expand options for antibacterial therapies but have not been
systematically tested in Gram-positive species. We profiled~ 8,000 combinations of 65 …

Challenges of identifying clinically actionable genetic variants for precision medicine

TC Carter, MM He - Journal of healthcare engineering, 2016 - Wiley Online Library
Advances in genomic medicine have the potential to change the way we treat human
disease, but translating these advances into reality for improving healthcare outcomes …

Staphylococcus edaphicus sp. nov., Isolated in Antarctica, Harbors the mecC Gene and Genomic Islands with a Suspected Role in Adaptation to Extreme …

R Pantůček, I Sedláček, A Indráková… - Applied and …, 2018 - Am Soc Microbiol
Two Gram-stain-positive, coagulase-negative staphylococcal strains were isolated from
abiotic sources comprising stone fragments and sandy soil in James Ross Island, Antarctica …

Comparative genomic analysis of Staphylococcus lugdunensis shows a closed pan-genome and multiple barriers to horizontal gene transfer

X Argemi, D Matelska, K Ginalski, P Riegel… - BMC genomics, 2018 - Springer
Abstract Background Coagulase negative staphylococci (CoNS) are commensal bacteria on
human skin. Staphylococcus lugdunensis is a unique CoNS which produces various …

The Role of Nanoscale Distribution of Fibronectin in the Adhesion of Staphylococcus aureus Studied by Protein Patterning and DNA-PAINT

H Khateb, RS Sørensen, K Cramer, AS Eklund… - ACS …, 2022 - ACS Publications
Staphylococcus aureus is a widespread and highly virulent pathogen that can cause
superficial and invasive infections. Interactions between S. aureus surface receptors and the …

Multiple bacteria identification in the point-of-care: An old method serving a new approach

S Viveiros, M Rodrigues, D Albuquerque, SAM Martins… - Sensors, 2020 - mdpi.com
The accurate diagnosis of bacterial infections is of critical importance for effective treatment
decisions. Due to the multietiologic nature of most infectious diseases, multiplex assays are …

The evolution of diverse antimicrobial responses in vancomycin-intermediate Staphylococcus aureus and its therapeutic implications

D Crozier, JM Gray, JA Maltas, RA Bonomo, KJ Card… - bioRxiv, 2023 - biorxiv.org
Staphylococcus aureus causes serious clinical infections, including bacteremia and
endocarditis. When clinicians suspect these diseases, they prescribe broad-spectrum …

Draft Genome Sequences of 64 Type Strains of 50 Species and 25 Subspecies of the Genus Staphylococcus Rosenbach 1884

K Cole, D Foster, JE Russell, T Golubchik… - Microbiology …, 2019 - Am Soc Microbiol
Members of the genus Staphylococcus have been isolated from humans, animals, and the
environment. Accurate identification with whole-genome sequencing requires access to data …

Complete genome sequence of a methicillin-resistant Staphylococcus lugdunensis strain and characteristics of its staphylococcal cassette chromosome mec

R Shibuya, Y Uehara, T Baba, K Teruya, K Satou… - Scientific reports, 2020 - nature.com
Symptoms of Staphylococcus lugdunensis infection are often similar to those of
Staphylococcus aureus infection, including skin and soft-tissue lesions, bacteremia and …