From haematopoietic stem cells to complex differentiation landscapes
E Laurenti, B Göttgens - Nature, 2018 - nature.com
The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …
model for stem-cell research, with the haematopoietic differentiation tree being widely used …
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML
For two decades, leukaemia stem cells (LSCs) in chronic myeloid leukaemia (CML) and
acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell …
acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell …
Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis
Bone marrow transplantation therapy relies on the life-long regenerative capacity of
haematopoietic stem cells (HSCs),. HSCs present a complex variety of regenerative …
haematopoietic stem cells (HSCs),. HSCs present a complex variety of regenerative …
Aging of hematopoietic stem cells
G de Haan, SS Lazare - Blood, The Journal of the American …, 2018 - ashpublications.org
Hematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout
life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas …
life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas …
Evolution of the cancer stem cell model
Genetic analyses have shaped much of our understanding of cancer. However, it is
becoming increasingly clear that cancer cells display features of normal tissue organization …
becoming increasingly clear that cancer cells display features of normal tissue organization …
The chronic myeloid leukemia stem cell: stemming the tide of persistence
TL Holyoake, D Vetrie - Blood, The Journal of the American …, 2017 - ashpublications.org
Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-
ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self …
ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self …
Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal
I Fares, J Chagraoui, Y Gareau, S Gingras, R Ruel… - Science, 2014 - science.org
The small number of hematopoietic stem and progenitor cells in cord blood units limits their
widespread use in human transplant protocols. We identified a family of chemically related …
widespread use in human transplant protocols. We identified a family of chemically related …
Hematopoietic stem cell heterogeneity and age-associated platelet bias are evolutionarily conserved
M Aksöz, GA Gafencu, B Stoilova, M Buono… - Science …, 2024 - science.org
Hematopoietic stem cells (HSCs) reconstitute multilineage human hematopoiesis after
clinical bone marrow (BM) transplantation and are the cells of origin of some hematological …
clinical bone marrow (BM) transplantation and are the cells of origin of some hematological …
In vivo tracking of human hematopoiesis reveals patterns of clonal dynamics during early and steady-state reconstitution phases
Hematopoietic stem/progenitor cells (HSPCs) are capable of supporting the lifelong
production of blood cells exerting a wide spectrum of functions. Lentiviral vector HSPC gene …
production of blood cells exerting a wide spectrum of functions. Lentiviral vector HSPC gene …
EPCR expression marks UM171-expanded CD34+ cord blood stem cells
I Fares, J Chagraoui, B Lehnertz… - Blood, The Journal …, 2017 - ashpublications.org
A small subset of human cord blood CD34+ cells express endothelial protein C receptor
(EPCR/CD201/PROCR) when exposed to the hematopoietic stem cell (HSC) self-renewal …
(EPCR/CD201/PROCR) when exposed to the hematopoietic stem cell (HSC) self-renewal …