ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
CW Wang, HC Chuang, TH Tan - Journal of Biomedical Science, 2023 - Springer
Abstract Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-
angiotensin system, provides protection against several chronic diseases. Besides chronic …
angiotensin system, provides protection against several chronic diseases. Besides chronic …
Immune dysregulation and the increased risk of complications and mortality following respiratory tract infections in adults with down syndrome
The risk of severe outcomes following respiratory tract infections is significantly increased in
individuals over 60 years, especially in those with chronic medical conditions, ie …
individuals over 60 years, especially in those with chronic medical conditions, ie …
Understanding inequalities in COVID-19 outcomes following hospital admission for people with intellectual disability compared to the general population: a matched …
Objectives This study explores the hospital journey of patients with intellectual disabilities
(IDs) compared with the general population after admission for COVID-19 during the first …
(IDs) compared with the general population after admission for COVID-19 during the first …
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner
Identifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding …
(SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding …
Aging with Down syndrome—where are we now and where are we going?
MJ Alldred, AC Martini, D Patterson, J Hendrix… - Journal of clinical …, 2021 - mdpi.com
Down syndrome (DS) is a form of accelerated aging, and people with DS are highly prone to
aging-related conditions that include vascular and neurological disorders. Due to the …
aging-related conditions that include vascular and neurological disorders. Due to the …
Time to be counted: COVID-19 and intellectual and developmental disabilities—An RSC Policy Briefing
The COVID-19 pandemic has impacted the lives and well-being of all people globally, with
consequences being observed across all domains from physical and mental health, to …
consequences being observed across all domains from physical and mental health, to …
[HTML][HTML] Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome
SL Hartley, V Fleming, B Piro-Gambetti, A Cohen… - Disability and Health …, 2022 - Elsevier
Abstract Background The Down syndrome population has been disproportionately affected
by Coronavirus 2019 (COVID-19) in terms of experiencing severe illness and death. Societal …
by Coronavirus 2019 (COVID-19) in terms of experiencing severe illness and death. Societal …
Clinical characteristics and comorbidities of COVID-19 in unvaccinated patients with Down syndrome: first year report in Brazil
Patients with Down syndrome (DS) are more affected by the Coronavirus Disease (COVID)-
19 pandemic when compared with other populations. Therefore, the primary aim of our study …
19 pandemic when compared with other populations. Therefore, the primary aim of our study …
COVID-19 vaccination for people with disabilities
Internationally, people with disabilities have been disproportionately impacted by COVID-19,
accounting for nearly 60% of COVID-19 deaths in the UK and overall higher mortality rates …
accounting for nearly 60% of COVID-19 deaths in the UK and overall higher mortality rates …
COVID-19 vaccination of individuals with Down syndrome—data from the Trisomy 21 Research Society Survey on safety, efficacy, and factors associated with the …
A Hüls, PT Feany, SI Zisman, ACS Costa, M Dierssen… - Vaccines, 2022 - mdpi.com
Individuals with Down syndrome (DS) are among the groups with the highest risk for severe
COVID-19. Better understanding of the efficacy and risks of COVID-19 vaccines for …
COVID-19. Better understanding of the efficacy and risks of COVID-19 vaccines for …