Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis.
PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body …

Associations between per-and polyfluoroalkyl substances (PFASs) and increased blood
lipids have been repeatedly observed in humans, but a causal relation has been debated …

Abstract The European Commission asked EFSA for a scientific evaluation on the risks to
human health related to the presence of perfluorooctane sulfonic acid (PFOS) and …

The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor that is abundantly expressed in liver. PPARα is activated by fatty acids and various …

Hexafluoropropylene oxide dimer acid (HFPO-DA or GenX) is an industrial replacement for
the straight-chain perfluoroalkyl substance (PFAS), perfluorooctanoic acid (PFOA) …

Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …

Long-chain perfluoroalkylated acids are persistent in the environment, leading to ubiquitous
exposure of biota. They have been listed as very persistent, very bioaccumulative and toxic …

Ligand-activated nuclear receptors, including peroxisome proliferator-activated receptor
alpha (PPARα), pregnane X receptor, and constitutive androstane receptor, were first …

Persistent presence of perfluoroalkyl acids (PFAAs) in the environment is due to their
extensive use in industrial and consumer products, and their slow decay. Biochemical tests …

As an emerging persistent organic pollutant (POP), perfluorooctanoate (PFOA) is one of the
most abundant perfluorinated compounds (PFCs) in the environment. This review …