Galectins are a family of proteins that bind to specific glycans thereby deciphering the
information captured within the glycome. In the last two decades, several galectin family …

The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

Galectins are a family of animal lectins that bind β-galactosides. Outside the cell, galectins
bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular …

Abstract Galectin-9 (Gal-9) is a β-galactoside binding lectin known for its immunomodulatory
role in various microbial infections. Gal-9 is expressed in all organ systems and localized in …

It has become evident that tumor-induced immuno-suppressive factors in the tumor
microenvironment play a major role in suppressing normal functions of effector T cells …

Galectins are among the most widely expressed class of lectins in all organisms. They
typically bind β-galactose-containing glycoconjugates and share primary structural …

Tumor cells exhibit striking changes in cell surface glycosylation as a consequence of
dysregulated glycosyltransferases and glycosidases. In particular, an increase in the …

Galectins are a family of mammalian carbohydrate-binding proteins expressed by many cell
types. Galectins can function intracellularly and can also be secreted to bind to cell surface …

Galectin-3 is a member of the galectin family, which consists of animal lectins that bind β-
galactosides. Recently, a role for galectin-3 in the pathophysiology of heart failure has been …

The role of inflammation in carcinogenesis has been extensively investigated and well
documented. Many biochemical processes that are altered during chronic inflammation …