Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important
roles in synaptic development and plasticity. While its importance in fundamental physiology …

Replicated international studies have underscored the human and societal costs associated
with major depressive disorder. Despite the proven efficacy of monoamine-based …

Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …

Importance Preexisting noncommunicable diseases (eg, diabetes) increase the risk of
COVID-19 infection, hospitalization, and death. Mood disorders are associated with …

Observational studies have reported the correlations between brain imaging-derived
phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal …

Bipolar disorder is heterogeneous in phenomenology, illness trajectory, and response to
treatment. Despite evidence for the efficacy of multimodality interventions, the majority of …

A systematic review and random-effects model network meta-analysis was conducted to
compare the efficacy, acceptability, tolerability, and safety of pharmacological interventions …

The involvement of the gut microbiota and the metabolites of colon-residing bacteria in brain
disease pathogenesis has been covered in a growing number of studies, but comparative …

Objectives To provide a succinct, clinically useful summary of the management of bipolar
disorder, based on the 2020 Royal Australian and New Zealand College of Psychiatrists …

Nearly all psychiatric diseases involve alterations in subjective, lived experience. The
scientific study of the biological basis of mental illness has generally focused on objective …