Novel approaches, drug candidates, and targets in pain drug discovery
Because of the problems associated with opioids, drug discovery efforts have been
employed to develop opioids with reduced side effects using approaches such as biased …
employed to develop opioids with reduced side effects using approaches such as biased …
GPR35: from enigma to therapeutic target
G Milligan - Trends in Pharmacological Sciences, 2023 - cell.com
The orphan G-protein-coupled receptor 35 (GPR35), although poorly characterised, is
attracting considerable interest as a therapeutic target. Marked differences in pharmacology …
attracting considerable interest as a therapeutic target. Marked differences in pharmacology …
Diverse and efficient catalytic applications of new cockscomb flower-like Fe 3 O 4@ SiO 2@ KCC-1@ MPTMS@ Cu II mesoporous nanocomposite in the …
MH Galehban, B Zeynizadeh, H Mousavi - RSC advances, 2022 - pubs.rsc.org
In this research, Fe3O4@ SiO2@ KCC-1@ MPTMS@ CuII as a new cockscomb flower-like
mesoporous nanocomposite was prepared and characterized by various techniques …
mesoporous nanocomposite was prepared and characterized by various techniques …
Rational designing of peptide-ligand conjugates-based immunotherapy for the treatment of complicated malaria
Aims Malaria deaths occur primarily due to complicated malaria associated with the
sequestration of Plasmodium falciparum-infected erythrocyte (Pf IE) in the capillary …
sequestration of Plasmodium falciparum-infected erythrocyte (Pf IE) in the capillary …
Aminosalicylates target GPR35, partly contributing to the prevention of DSS-induced colitis
W Otkur, J Wang, T Hou, F Liu, R Yang, Y Li… - European Journal of …, 2023 - Elsevier
Abstract GPR35, a class A G-protein-coupled receptor, is considered an orphan receptor;
the endogenous ligand and precise physiological function of GPR35 remain obscure …
the endogenous ligand and precise physiological function of GPR35 remain obscure …
Syntheses, reactivity, and biological applications of coumarins
This comprehensive review, covering 2021–2023, explores the multifaceted chemical and
pharmacological potential of coumarins, emphasizing their significance as versatile natural …
pharmacological potential of coumarins, emphasizing their significance as versatile natural …
Visible‐Light‐Induced Regioselective Deaminative Alkylation of Coumarins via Photoredox Catalysis
M Tao, AJ Wang, P Guo, W Li, L Zhao… - Advanced Synthesis …, 2022 - Wiley Online Library
Alkylated coumarins have many applications in medicinal chemistry, however, methods
access to such structures are still limited. Herein, we report a site‐selective photocatalytic …
access to such structures are still limited. Herein, we report a site‐selective photocatalytic …
[HTML][HTML] In vitro antimicrobial combat, molecular modelling and structure activity relationship studies of novel class of aryl-ethyne tethered coumarin analogues and …
P Prabhala, SM Sutar, HM Savanur, SD Joshi… - European Journal of …, 2022 - Elsevier
A series of novel class of aryl ethyne-tethered coumarin analogues (series 1) and some 3-
aryl coumarin cognates (series 2) were synthesized, and their in vitro antimicrobial activities …
aryl coumarin cognates (series 2) were synthesized, and their in vitro antimicrobial activities …
Visible-Light-Induced C(sp2)–C(sp3) Coupling Reaction for the Regioselective Synthesis of 3-Functionalized Coumarins
K Zhang, L Qiao, J Xie, Z Lin, H Li, P Lu… - The Journal of Organic …, 2021 - ACS Publications
A photocatalysis strategy for the regioselective synthesis of 3-functionalized coumarins is
reported. With visible light irradiation, a direct and regioselective C (sp2)–C (sp3) coupling …
reported. With visible light irradiation, a direct and regioselective C (sp2)–C (sp3) coupling …
Photocatalytic dehydrogenative oxidation/amination of 2-alkyl benzamides under transition-metal-free conditions
Y Yu, Z Liang, L Zhang, Y Lin, M Liu, S Wang… - Organic Chemistry …, 2023 - pubs.rsc.org
A mild pathway is reported herein for converting 2-alkyl benzamides into functionalized
hydroxyisoindolines under visible light stimulation using oxygen as the sole terminal oxidant …
hydroxyisoindolines under visible light stimulation using oxygen as the sole terminal oxidant …