Novel approaches, drug candidates, and targets in pain drug discovery

S Obeng, T Hiranita, F León, LR McMahon… - Journal of medicinal …, 2021 - ACS Publications
Because of the problems associated with opioids, drug discovery efforts have been
employed to develop opioids with reduced side effects using approaches such as biased …

GPR35: from enigma to therapeutic target

G Milligan - Trends in Pharmacological Sciences, 2023 - cell.com
The orphan G-protein-coupled receptor 35 (GPR35), although poorly characterised, is
attracting considerable interest as a therapeutic target. Marked differences in pharmacology …

Diverse and efficient catalytic applications of new cockscomb flower-like Fe 3 O 4@ SiO 2@ KCC-1@ MPTMS@ Cu II mesoporous nanocomposite in the …

MH Galehban, B Zeynizadeh, H Mousavi - RSC advances, 2022 - pubs.rsc.org
In this research, Fe3O4@ SiO2@ KCC-1@ MPTMS@ CuII as a new cockscomb flower-like
mesoporous nanocomposite was prepared and characterized by various techniques …

Rational designing of peptide-ligand conjugates-based immunotherapy for the treatment of complicated malaria

P Godara, B Naik, R Meghwal, R Ojha, V Srivastava… - Life Sciences, 2022 - Elsevier
Aims Malaria deaths occur primarily due to complicated malaria associated with the
sequestration of Plasmodium falciparum-infected erythrocyte (Pf IE) in the capillary …

Aminosalicylates target GPR35, partly contributing to the prevention of DSS-induced colitis

W Otkur, J Wang, T Hou, F Liu, R Yang, Y Li… - European Journal of …, 2023 - Elsevier
Abstract GPR35, a class A G-protein-coupled receptor, is considered an orphan receptor;
the endogenous ligand and precise physiological function of GPR35 remain obscure …

Syntheses, reactivity, and biological applications of coumarins

A Citarella, S Vittorio, C Dank, L Ielo - Frontiers in Chemistry, 2024 - frontiersin.org
This comprehensive review, covering 2021–2023, explores the multifaceted chemical and
pharmacological potential of coumarins, emphasizing their significance as versatile natural …

Visible‐Light‐Induced Regioselective Deaminative Alkylation of Coumarins via Photoredox Catalysis

M Tao, AJ Wang, P Guo, W Li, L Zhao… - Advanced Synthesis …, 2022 - Wiley Online Library
Alkylated coumarins have many applications in medicinal chemistry, however, methods
access to such structures are still limited. Herein, we report a site‐selective photocatalytic …

[HTML][HTML] In vitro antimicrobial combat, molecular modelling and structure activity relationship studies of novel class of aryl-ethyne tethered coumarin analogues and …

P Prabhala, SM Sutar, HM Savanur, SD Joshi… - European Journal of …, 2022 - Elsevier
A series of novel class of aryl ethyne-tethered coumarin analogues (series 1) and some 3-
aryl coumarin cognates (series 2) were synthesized, and their in vitro antimicrobial activities …

Visible-Light-Induced C(sp2)–C(sp3) Coupling Reaction for the Regioselective Synthesis of 3-Functionalized Coumarins

K Zhang, L Qiao, J Xie, Z Lin, H Li, P Lu… - The Journal of Organic …, 2021 - ACS Publications
A photocatalysis strategy for the regioselective synthesis of 3-functionalized coumarins is
reported. With visible light irradiation, a direct and regioselective C (sp2)–C (sp3) coupling …

Photocatalytic dehydrogenative oxidation/amination of 2-alkyl benzamides under transition-metal-free conditions

Y Yu, Z Liang, L Zhang, Y Lin, M Liu, S Wang… - Organic Chemistry …, 2023 - pubs.rsc.org
A mild pathway is reported herein for converting 2-alkyl benzamides into functionalized
hydroxyisoindolines under visible light stimulation using oxygen as the sole terminal oxidant …