Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …

According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a
ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin–RING …

Despite the diverse biological pathways known to be regulated by ubiquitylation, global
identification of substrates that are targeted for ubiquitylation has remained a challenge. To …

Identifying the interactions established by a protein of interest can be a critical step in
understanding its function. This is especially true when an unknown protein of interest is …

Cullin-RING ligases (CRLs) comprise the largest ubiquitin E3 subclass, in which a central
cullin subunit links a substrate-binding adaptor with an E2-binding RING. Covalent …

The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double
RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain …

The eukaryotic ubiquitin family encompasses nearly 20 proteins that are involved in the
posttranslational modification of various macromolecules. The ubiquitin-like proteins (UBLs) …

In the last decade, the ubiquitin–proteasome system has emerged as a valid target for the
development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets …

Neddylation is the post‐translational protein modification that is most closely related to
ubiquitination. However, ubiquitination is known to regulate a myriad of processes in …